NMN helps against lung cancer
Feb 25, 2025
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"The study results showed that local treatment with high-dose NMN strongly inhibited tumor growth and induced tumor ferroptosis in lung adenocarcinoma cells. Specifically, we found that (i) high-dose NMN (100 mM) suppressed cell proliferation in lung adenocarcinoma A549 and SPCA1 cells and promoted cell death, whereas low-dose treatment (10 mM) produced the opposite effect; (ii) cell death induced by high-dose NMN occurred through ferroptosis; (iii) high-dose NMN treatment mainly induced intracellular NAM overload to trigger ferroptotic cell death; and (iiii) high-dose NMN induced tumor ferroptosis through a NAM-overload-mediated SIRT1-AMPK-ACC signaling pathway. Furthermore, we were able to show that combining the NAMPT inhibitor FK866, a potential tumor therapeutic, with high-dose local NMN treatment increased the effectiveness of tumor suppression in vitro and in vivo. Notably, the NAMPT inhibitor FK866 showed no appreciable antitumor effect as monotherapy in clinical trials [ ]. Our findings therefore suggest that patients with lung adenocarcinoma should consider two points when using NMN: dose and compatibility with medications affecting energy metabolism.
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Currently, the highest dose of NMN administered in various studies is 2000 mg/kg/day by oral gavage, which contributes to reduced body weight gain, reduced food intake and elevated ALT levels [ ]. In one study, the authors showed few dose-limiting toxicities with NMN administered by intraperitoneal injection or orally. "
