item_group_id,aid,name,brand,product_type,shop_cat,mpnr,ean,image,link,availability,price,stock_quantity,dlv_cost,dlv_cost_AT,dlv_time,weight,meta_p_short_desc,description,unit,quantity,price_per_unit,price_per_gram,price_per_milligram,price_per_milliliter 9885493363021,50736709730637,"AFEGA® NMN Powder – 50 g","AFEGA® Anti-Aging-Produkte","AFEGA-SUBSTANCE","AFEGA® und UTHEVER® > Alle Produkte > Bestseller > Energie & Stoffwechsel > META-SALES Sortiment > NMN > pets/horses > Regeneration & Zellschutz > Sonderangebote > Vorsorge","NMN-50-1","0649812604930","https://www.afega.shop/cdn/shop/files/afega-nmn-pulverbox.webp?v=1776354925&width=1000","https://www.afega.shop/en/products/nmn-pulver-50g?variant=50736709730637&utm_source=web&utm_medium=cpc&utm_campaign=billiger","in stock",36.05,13,6.50,15,"3-4 Tage","0.1 kg","50g NMN-Pulver Reinheit > 99% CAS 1094-61-7Lagerung: NMN ist bei Raumtemperatur stabil und MINDESTENS 2 Jahre haltbar.Bitte beachten Sie den Rabattcode (in der Artikelbeschreibung) beim Kauf von (mindestens) 5 Dosen.Und werfen Sie unbedingt einen Blick auf unser neues Produkt: liposomales NMN!Hinweis: Diesem Produkt liegt kein Dosierloeffel bei.","AFEGA® NMN powder 50 g is intended for people who want to dose nicotinamide mononucleotide flexibly and prefer to use it in powder form. This product is particularly suitable for users who prefer not to take capsules and want to tailor their routine to their individual needs.NMN is one of the best-known NAD+ precursors and is mainly discussed in relation to cellular energy metabolism and healthy aging. The powder format allows flexible dosing and is the simplest option for many users seeking flexibility and value for money.Quality50 g NMN powderPurity: > 99%CAS: 1094-61-7StorageNMN is stable at room temperature and has a shelf life of at least 2 years. Store in a dry place protected from light and keep the container tightly closed.How we source our productWe do not always source our own-brand NMN from a single manufacturer. We negotiate with different manufacturers and select a supplier that meets our quality requirements while offering a favorable purchase price. This enables us to offer this product at an attractive price.If consistent color texture and granulation from batch to batch are particularly important to you UTHEVER® NMN is the more suitable choice.DosageFor information on dosage please see the related blog post by Dr. Peter Niehenke.Why we do not include measuring spoonsSome customers expect powder products to include a measuring spoon. We deliberately do not include one: powders differ in their bulk density and particle size. These properties can also vary between batches of the same product. The same spoon volume therefore does not always correspond to the same amount of powder.Many customers use several powder products so different measuring spoons that look alike can quickly accumulate. This can easily lead to confusion in everyday use.For dosing as accurately as possible we therefore recommend a suitable digital precision scale with a resolution appropriate to the stated dose. Such scales are available at affordable prices.Orders of multiple containersIf you order more than 4 containers enter the discount code NMN-50 at checkout to receive a 7.5% discount on this item.","g","50","","0.72","","" 9885493395789,50736709763405,"AFEGA® NMN Powder – 250 g","AFEGA® Anti-Aging-Produkte","AFEGA-SUBSTANCE","AFEGA® und UTHEVER® > Alle Produkte > billiger > Energie & Stoffwechsel > META-SALES Sortiment > NMN > pets/horses > Regeneration & Zellschutz > Sonderangebote > Vorsorge","NMN-250-1","0649812604893","https://www.afega.shop/cdn/shop/files/afega-nmn-dose.webp?v=1776354822&width=1000","https://www.afega.shop/en/products/nmn-pulver-250g?variant=50736709763405&utm_source=web&utm_medium=cpc&utm_campaign=billiger","in stock",150.42,6,0,15,"3-4 Tage","0.35 kg","250 g NMN powder purity > 99% CAS 1094-61-7 Storage: NMN is stable at room temperature and has a shelf life of AT LEAST 2 years. If you order more than 3 containers please enter the discount code "nmn-1000" at checkout to receive a 15% discount on the net price (the price excluding VAT). And be sure to take a look at our new product: liposomal NMN!Note: This product does not include a measuring spoon.","AFEGA® NMN Powder 250 g is the larger pack for those who want to dose nicotinamide mononucleotide flexibly and prefer to use it in powder form. This package is especially suitable for users who plan their routine for the long term and do not want to reorder frequently.NMN is one of the best-known NAD+ precursors and is mainly discussed in connection with cellular energy metabolism and healthy aging. The powder format offers maximum dosing flexibility and is the most practical option for many users who want larger quantities and good value for money.Quality250 g NMN powderPurity: > 99 %CAS: 1094-61-7StorageNMN is stable at room temperature and has a shelf life of at least 2 years. Store in a dry place protected from light and keep the container tightly closed.The larger packThe 250 g package is intended for people who want to make NMN a planned long-term part of their routine rather than use it only occasionally. The larger package reduces the need to reorder and is particularly suitable for users who deliberately prefer powder to capsules.How we source our productWe do not always source our own-brand NMN from a single manufacturer. We negotiate with different manufacturers and select a supplier that meets our quality requirements while offering a favorable purchase price. This enables us to offer this product at an attractive price.If it is particularly important to you that color consistency and granulation remain as consistent as possible from batch to batch UTHEVER® NMN is the more suitable choice.DosageFor information on dosage please see the related blog post by Dr. Peter Niehenke.Why We Do Not Include a Measuring SpoonSome customers expect powder products to include a measuring spoon. We deliberately do not include one: powders differ in their bulk density and particle size. These properties can also vary between batches of the same product. Therefore the same spoon volume does not always correspond to the same amount of powder.Since many customers use several powder products different similar-looking measuring spoons can quickly accumulate. This can easily lead to confusion in everyday use.For dosing as accurately as possible we therefore recommend a suitable digital precision scale with a resolution appropriate to the stated dose. Such scales are available at affordable prices.","g","250","","0.6","","" 9885494542669,50736711696717,"AFEGA® TMG / Trimethylglycine – 150 g Powder","AFEGA® Anti-Aging-Produkte","AFEGA-SUBSTANCE","AFEGA® und UTHEVER® > Alle Produkte > Betain/TMG > Energie & Stoffwechsel > META-SALES Sortiment > pets/horses > Regeneration & Zellschutz > Vorsorge","BET-2","0737925942770","https://www.afega.shop/cdn/shop/files/afega-betain-dose.webp?v=1776352460&width=1000","https://www.afega.shop/en/products/tmg-trimethylglycin-pulver-150g?variant=50736711696717&utm_source=web&utm_medium=cpc&utm_campaign=billiger","in stock",13.87,5,6.50,15,"3-4 Tage","0.2 kg","150 g Trimethylglycin Pulver (Betain Pulver) CAS 107-43-7TROCKEN LAGERN !","AFEGA® TMG / Trimethylglycine 150 g is a powder product for people who specifically want to use a methyl donor. TMG also known as betaine is particularly relevant in discussions about methylation homocysteine metabolism and its use as a practical addition to certain routines.Many users explore TMG when they use NMN or other NAD+ precursors. The reasoning is that methyl groups may be needed during the processing of nicotinamide. This question is discussed in research but has not been conclusively resolved in every respect. TMG is often viewed as a practical accompanying component in this context.Product details150 g TMG / trimethylglycine powderAlso known as betaineWhy some users are interested in TMGTMG is known as a methyl donor. Methyl groups play a role in many biochemical processes including methylation pathways. TMG is therefore often mentioned in connection with homocysteine methylation balance and certain supplement routines.TMG in the context of NMNIn discussions about NMN a common question is whether a higher intake of NAD+ precursors can affect the need for methyl groups. This provides a plausible reason why many users include TMG as an additional component. However not every question on this subject has been conclusively resolved scientifically. TMG should therefore be viewed less as a strict requirement and more as a potentially useful accompanying component of certain routines.The difference between TMG and betaine HClTMG also called betaine is the form mainly discussed as a methyl donor. Betaine HCl additionally contains hydrochloride and is used in a different context primarily to support stomach acid. This product contains TMG without HCl.Choosing this formatThe powder format suits users who want to dose TMG flexibly and incorporate it into their existing routine. The 150 g pack is a practical size for planned regular use.DosageFor information on dosage please see the related blog post by Dr. Peter Niehenke.Who may be interested in this product?People who specifically want to use a methyl donorUsers who want to understand TMG in the context of NMN or other NAD+ precursorsAnyone who wants to dose trimethylglycine flexibly in powder formFurther informationMore detailed information on TMG and other substances is available on the Facebook page run by the AFEGA Research Group.","g","150","","0.09","","" 9885493821773,50736710615373,"AFEGA® NMN Powder – 1 kg","AFEGA® Anti-Aging-Produkte","AFEGA-SUBSTANCE","AFEGA® und UTHEVER® > Alle Produkte > billiger > Energie & Stoffwechsel > META-SALES Sortiment > NMN > pets/horses > Regeneration & Zellschutz > Vorsorge","NMN-1000-1","0737925943036","https://www.afega.shop/cdn/shop/files/afega-nmn-pulver-tuete.webp?v=1776354380&width=1000","https://www.afega.shop/en/products/nmn-pulver-1kg?variant=50736710615373&utm_source=web&utm_medium=cpc&utm_campaign=billiger","in stock",444.54,3,0,0,"3-4 Tage","1.3 kg","1 kg NMN powder purity > 99% CAS 1094-61-7 Storage: NMN is stable at room temperature and has a shelf life of AT LEAST 2 years. If you order at least 3 kg of NMN please enter the discount code "NMN-3000" at checkout and you will receive 10%% discount on this item.","AFEGA® NMN Powder 1 kg is a bulk pack for those who want flexible dosing and plan to include nicotinamide mononucleotide in their routine over the long term. This format is designed especially for users who prefer powder and want to reduce the need to reorder.NMN is one of the best-known NAD+ precursors and is mainly discussed in connection with cellular energy metabolism and healthy aging. The powder format offers maximum dosing flexibility and is often the most practical option for people who use larger quantities and want to manage their own routine.Quality1 kg NMN powderPurity: > 99 %CAS: 1094-61-7StorageNMN is stable at room temperature and has a shelf life of at least 2 years. Store in a dry place protected from light and keep the container tightly closed.Why choose the bulk packThe 1 kg pack is intended for people who plan to use NMN over longer periods and prefer a large powder package. This reduces the need to reorder while keeping dosing flexible.How we source our productWe do not always source our own-brand NMN from a single manufacturer. We negotiate with different manufacturers and select a supplier that meets our quality requirements while offering a favorable purchase price. This enables us to offer this product at an attractive price.If it is particularly important to you that color consistency and granulation remain as consistent as possible from batch to batch then UTHEVER® NMN is the more suitable choice.DosageFor information on dosage please see the related blog post by Dr. Peter Niehenke.Why We Do Not Include Measuring SpoonsSome customers expect powder products to include a measuring spoon. We deliberately do not include one: powders differ in their bulk density and particle size. These properties can also vary between batches of the same product. The same spoon volume therefore does not always correspond to the same amount of powder.Since many customers use several powder products different similar-looking measuring spoons can quickly accumulate. This can easily lead to confusion in everyday use.For dosing as accurately as possible we therefore recommend a suitable digital precision scale with a resolution appropriate to the stated dose. Such scales are available at affordable prices.Further InformationMore detailed information about NMN and other substances can be found on the AFEGA Research Group operated Facebook page.","g","1000","","0.44","","" 9885497360717,50736715661645,"AFEGA® TMG / Trimethylglycine – 1 kg Powder","AFEGA® Anti-Aging-Produkte","AFEGA-SUBSTANCE","AFEGA® und UTHEVER® > Alle Produkte > Betain/TMG > billiger > Energie & Stoffwechsel > META-SALES Sortiment > pets/horses > Regeneration & Zellschutz > Vorsorge","BET-3","630606562918","https://www.afega.shop/cdn/shop/files/afega-betain-tuete.webp?v=1776183552&width=1000","https://www.afega.shop/en/products/tmg-trimethylglycin-pulver-1kg?variant=50736715661645&utm_source=web&utm_medium=cpc&utm_campaign=billiger","in stock",75.21,4,6.50,15,"3-4 Tage","1.2 kg","1 kg Trimethylglycin Pulver (Betain Pulver) CAS 107-43-7 ","AFEGA® TMG / Trimethylglycine supplied as 1 kg of powder is intended for those who specifically want to use a methyl-group donor with flexible dosing. TMG also known as betaine is discussed particularly in relation to methylation homocysteine metabolismand its practical use in certain routines.Many users consider TMG particularly when using NMN or other NAD+ precursors. This is based on the idea that methyl groups may be required when nicotinamide is metabolised. This question is discussed in research but not every aspect has been conclusively resolved. In this context TMG is often viewed as a practical addition.Product data1 kg TMG / Trimethylglycine powderalso known as BetaineWhy some users may consider TMGTMG is known as a methyl group donor. Methyl groups play a role in many biochemical processes including methylation pathways. TMG is therefore often mentioned in relation to homocysteine methylation balance and certain supplement routines.Context in relation to NMNIn discussions about NMN a recurring question is whether higher intake of NAD+ precursors can affect the need for methyl groups. This is a plausible reason why many users consider adding TMG to their routine. At the same time not every question about this has been conclusively resolved by research. TMG should therefore be viewed as a potentially useful addition to certain routines rather than as a strict requirement.TMG and Betaine HCl – the differenceTMG or Betaine is the form that is mainly discussed as a methyl group donor. Betaine HCl additionally contains hydrochloride and is used in a different context namely primarily to support stomach acid. This product contains TMG without HCl.Why choose the bulk packThe 1 kg package is intended for users who want flexible dosing and plan to include TMG in their routine over the long term. The large package substantially reduces the need to reorder and is particularly suitable for people who deliberately prefer powder to capsules.DosageFor information on dosage please see the related blog post by Dr. Peter Niehenke.Why we do not include measuring spoonsSome customers expect powder products to include a measuring spoon. We deliberately refrain from this: powders differ in their bulk density and grain size. These properties can also vary between batches of the same product. The same spoon volume therefore does not always correspond to the same amount of powder.Since many customers use several powder products different similar-looking measuring spoons can quickly accumulate. This can easily lead to confusion in everyday use.For the most accurate dosing we therefore recommend a suitable digital precision scale with a resolution matching the specified dosing amount. Such scales are available at affordable prices.Who this product may suitfor people who want to work specifically with a methyl group donorfor users who want to understand TMG in relation to NMN or other NAD+ precursorsfor everyone who wants to dose trimethylglycine flexibly in powder formFurther informationMore detailed information about TMG and other substances can be found on the AFEGA Research Group operated Facebook page.","g","1000","","0.08","","" 10084683055437,51665795088717,"250 mg NAD (β-nicotinamide adenine dinucleotide oxidized form; CAS 53-84-9) – 1 vial of lyophilisate for reconstitution to 10 ml – Returns excluded – Imported product","AFEGA Research Group","China-Import","AFEGA® und UTHEVER® > Alle Produkte > ampullen > Bestseller > billiger > BLOG / Forschung > Energie & Stoffwechsel > Gedächtnis Fokus & "Senioren-Gehirn" > META-SALES Sortiment > NAD (Lyophilisate) > NAD+ > Regeneration & Zellschutz > Sonderangebote > Vorsorge","AFEGA-NAD-250","637962701708","https://www.afega.shop/cdn/shop/files/afega-nad-ampulle-lyophilisat.webp?v=1775315760&width=1000","https://www.afega.shop/en/products/nad-lyophilisat-250mg?variant=51665795088717&utm_source=web&utm_medium=cpc&utm_campaign=billiger","in stock",94.54,35,6.50,15,"3-4 Tage","0.017 kg","250 mg NAD+-Infusion (β-Nicotinamidadenindinukleotid; CAS 53-84-9) - Rückgabe ausgeschlossen! Staffelpreise! Bei Außentemperaturen von mehr als 18 Grad wird Gekühlter Versand empfohlen! (Link anklicken und zur Bestellung hinzufügen!) Importware (ISO 9001- und GMP-zertifiziert) - Staffelpreise","1 vial of lyophilisate for reconstitution to 10 ml : This vial contains a freeze-dried powder (lyophilisate). Before use it must be reconstituted (i.e. dissolved) with a solvent (e.g. sterile water).We strongly recommend our blog post on NAD infusions.Guarantee: Pharmaceutical quality. The manufacturer is ISO 9001 and GMP certified and the AFEGA Research Groupregularly checks the product’s quality.Minimum shelf life: When stored correctly at 2–8°C and protected from light all infusion products we distribute remain stable for at least one year from the date of sale without loss of quality .Volume discounts are listed at the bottom of this page. For outside temperatures above 18 °C refrigerated shipping is recommended. Click the link to add it to your order.*** Delivery to addresses outside the EU ***If the delivery address is outside the EU you bear the risk of any import problems in your country. Do not order before confirming that you are permitted to import these infusion products. For deliveries outside the EU we ship exclusively by express because refrigeration is required. Please select the appropriate shipping option at checkout!Please note: This product is excluded from the right of return due to special delivery requirements!Advantages of lyophilized (freeze-dried) NAD+ powder compared to other formsStability and shelf lifeLyophilised NAD+ powder is particularly stable and has a longshelf life because of the freeze-drying process. The removal of water protects the sensitive molecule from degradation by hydrolysis or microbial contamination which is a common problem in liquid solutions. This allows NAD+ powder to be stored for longer periods without significant loss of NAD+.Purity and dosing accuracy This lyophilised NAD+ is offered in pharmaceutical -grade or laboratory-grade quality. The powder can be precisely dosed and flexibly used for various applications (e.g. infusions injections cell culture). Compared to tablets or capsules which often contain fillers and excipients the powder offers a higher concentration of active ingredient and fewer impurities.Flexibility in use The powder can be reconstituted as needed for example with sterile saline for infusions or other suitable solvents for research purposes. This allows the concentration and method of administration to be adjusted individually which is not possible with premixed solutions or solid dosage forms.Transport and storage Lyophilized powder is lighter and more space-saving to transport than liquid preparations. It does not require a continuous cold chain as long as it is stored dry and protected from light which simplifies logistics and saves costs.Lower risk of chemical degradation In the dry state NAD+ is significantly less susceptible to oxidation and other chemical degradation processes than in solution ensuring quality until use.Sources:[1] https://ch.iherb.com/blog/nad-nmn-aging-benefits/1640[2] https://www.zentrum-der-gesundheit.de/ernaehrung/nahrungsergaenzung/weitere-nahrungsergaenzungsmittel/nad[3] https://www.orthoknowledge.eu/artikel/nad-und-alterung[4] https://www.krebsinformationsdienst.de/fachkreise/nachrichten/detail/nahrungsergaenzungsmittel-nadh-gegen-krebs[5] https://www.gesundheits-lexikon.com/Anti-Aging-Medizin/Schluesselgene-und-Signalwege-in-der-Anti-Aging-Forschung/NAD-und-sein-Einfluss-auf-das-Altern[6] https://www.klartext-nahrungsergaenzung.de/faq/projekt-klartext-nem/nad-und-nmn-in-nahrungsergaenzungsmitteln-38606[7] https://www.ganzimmun.de/fileadmin/user_upload/NAD_LIN0062_001.pdf******NAD+ (nicotinamide adenine dinucleotide) is an essential coenzyme found in every cell of the body and plays a central role in energy metabolism and cellular repair mechanisms. NAD+ levels in the body decrease with age which is associated with a variety of age-related health problems. NAD+ infusions where NAD+ is administered directly into the bloodstream have gained popularity in recent years. The following outlines the current state of scientific research on the benefits and risks of this therapy.Potential benefits of NAD+ infusions1. Support for cellular metabolism and energy productionNAD+ plays a central role in energy metabolism particularly in mitochondrial function ; mitochondriaare the cells’ “powerhouses”. Studies show that increasing NAD+ levels can improve mitochondrial function and promote cell health. (Verdin et al. Cell Metabolism 2015)2. Improvement of DNA repair and cellular stress responseNAD+ activates sirtuins and PARPs (poly-ADP-ribose polymerases) enzymes involved in DNA repair and regulation of cell stress. Higher NAD+ levels can therefore help reduce cell damage caused by aging and environmental factors. (Imai & Guarente Nature Reviews Molecular Cell Biology 2014)3. Neurological healthNAD+ is associated with neuronal function and the repair of neurological damage. Preliminary studies suggest that NAD+ infusions may be beneficial in neurodegenerative diseases such as Parkinsons and Alzheimers. (Braidy et al. Frontiers in Aging Neuroscience 2019)4. Potential support in substance-use disordersSome clinical reports suggest that NAD+ infusions may help alleviate withdrawal symptoms and stabilise brain chemistry in people with alcohol or drug dependence. (Ross et al. Journal of Substance Use 2018)5. Anti-ageing effectsLower NAD+ levels are associated with signs of ageing and chronic diseases. Animal studies show that increasing NAD+ levels can promote longevity. (Yoshino et al. Cell Metabolism 2018)Risks and side effects of NAD+ infusions1. Insufficient long-term studiesAlthough NAD+ infusions have shown positive results in pilot studies comprehensive long-term studies on safety and efficacy in humans are currently lacking.2. Acute side effectsSome patients have reported symptoms such as nausea headaches hot flashes and dizziness during or after NAD+ infusions. These side effects appear to be dose-dependent. (Bogan & Brenner Annual Review of Nutrition 2008)3. Possible effects on metabolismAn increased NAD+ level could theoretically affect the balance of other metabolic pathways. This could be problematic especially for people with metabolic disorders such as diabetes or certain cancers.4. Cost and accessibilityNAD+ infusions are expensive and are not currently included in established clinical guidelines. They may therefore be considered experimental therapy.5. Infusion-related risksAs with any intravenous therapy there is a small risk of infections thrombosis or allergic reactions.ConclusionNAD+ infusions show promise for supporting cellular health particularly in age-related conditions and certain neurological and metabolic disorders. However their use remains experimental.Sources:[1] https://www.medrxiv.org/content/10.1101/2024.06.06.24308565v1.full[2] https://vitalivtherapy.com.au/studies-on-the-benefits-of-nad/[3] https://biorestorehealth.com/newtown-connecticut/what-is-nad-iv-therapy-process-benefits-and-risks/[4] https://aestha.co.uk/nad-iv-drip/[5] https://pmc.ncbi.nlm.nih.gov/articles/PMC9512238/[6] https://www.azivmedics.com/side-effects-of-nad-therapy[7] https://www.impnaples.com/post/the-science-behind-nad-iv-therapy-benefits-risks-and-effectivenessWhy are infusions so expensive?Members of our research group use this powder to prepare infusions for their personal use. For us this is acceptable because we are relying on our own judgement ourselvesregarding purity and in particular the absence of microbial contamination. However if you professionally offer NAD infusions you have a special responsibility towards your patients/customers and therefore need a particularly high level of safety. Legally required extensive documentation by manufacturers is intended to provide this high level of assurance. These infusions are expensive not because the substance is purer or more effective but because extensive documentation requirements —under which every batch must be fully traceable from NAD productionto the final product—are intended to assure a high level of purity.Here is a doctor’s guide to administering an infusion.Volume discountsFrom 10 vials (one box): 10% – discount code at checkout: NAD-250-10 (delivery time: 3–4 days; Switzerland: 4–5 weeks) From 20 vials (2 boxes of 10): 15% – discount code at checkout: NAD-250-20 (delivery time: 3–4 days; Switzerland: 4–5 weeks) From 30 vials (3 boxes of 10): 20% – discount code at checkout: NAD-250-30 (delivery time: about 2 weeks; Switzerland: 4–5 weeks)From 50 vials (5 boxes of 10): 25% – discount code at checkout: NAD-250-50 (delivery time: about 2 weeks; Switzerland: 4–5 weeks) ","mg","250","","","0.38","" 9885500801357,50736719462733,"Liposomal Coenzyme AFEGA® Q10 Powder - 60 capsules of 143 mg each (=100 mg pure Q10)","Xi'an Natural Fields China","AFEGA-KAPSELN","AFEGA® und UTHEVER® > Alle Produkte > BLOG / Forschung > Coenzym Q10 / Ubiquinol > Erschöpfung & Muskelschwäche > Herz & Gefäße > META-SALES Sortiment","XI-Q10-60-K","637962701586","https://www.afega.shop/cdn/shop/files/afega-lipo-q10-dose.webp?v=1775346270&width=1000","https://www.afega.shop/en/products/liposomales-coenzym-afega-q10-pulver-60-kapseln-zu-je-143-mg-100-mg-reines-q10?variant=50736719462733&utm_source=web&utm_medium=cpc&utm_campaign=billiger","in stock",27.31,17,6.50,15,"3-4 Tage","0.102 kg","60 Kapseln zu je 143 mg liposomales Q10Im Kühlschrank lagern aber nicht tiefgefrieren (Substanzen mit einem Liposom dürfen nicht tiefgefroren werden.)Zusammensetzung:70% Q1015% Dextrin15% Phospholipids(Verzehrempfehlung: 1 Kapsel pro Tag entsprechend 100 mg Q10)","Coenzym Q10 (Ubiquinon) ist ein körpereigener Stoff der in Ihren Zellen dabei hilft aus Nahrung Energie zu machen. Man kann sich Q10 wie ein kleines „Zwischenstück“ im Kraftwerk der Zelle vorstellen: Ohne diesen Baustein läuft der Grundbetrieb weniger rund – vor allem in Geweben die dauerhaft Leistung brauchen.Was ist bei Q10 der Knackpunkt?Q10 ist fettlöslich. Und genau deshalb ist bei vielen Produkten nicht die Menge auf dem Etikett die entscheidende Frage sondern: Wie gut kommt es im Körper tatsächlich an?Warum liposomal?Liposomen sind winzige Fettkügelchen (Lipid-Doppelschicht) die einen Wirkstoff umhüllen können. Praktisch bedeutet das bei Q10:Besserer Transport im Verdauungsweg: Fettlösliche Stoffe brauchen passende „Mitnahme-Strukturen“ – Liposomen sind genau dafür gemacht.Schutz & Stabilität: Der Wirkstoff ist in einer Lipid-Hülle eingebettet und wird so auf dem Weg durch den Verdauungstrakt besser begleitet.Hinweise aus Studien: In Vergleichen zeigen liposomale Formen teils höhere und länger anhaltende Q10-Blutspiegel als nicht-liposomale Varianten.Was Sie bei uns konkret bekommenDarreichungsform: liposomales Q10-Pulver in KapselnInhalt: 60 KapselnPro Kapsel: 143 mg Mischung davon 100 mg reines Coenzym Q10VerzehrempfehlungSo wird Q10 in der Praxis meist sinnvoll eingesetzt: 1 Kapsel täglich zu einer Mahlzeit – idealerweise zu einer Mahlzeit die auch etwas Fett enthält.Für wen ist liposomales Q10 besonders naheliegend?Alltag & Belastbarkeit: wenn Sie den „Grundstrom“ Ihrer Zellenergie pragmatisch unterstützen möchtenSport & Aktivität: wenn Training/Bewegung regelmäßig dazugehörtMit zunehmendem Alter: wenn Q10 als klassischer Zellenergie-Baustein in Ihre Routine passtNahrungsergänzungsmittel sind kein Ersatz für eine ausgewogene Ernährung und eine gesunde Lebensweise.","capsule","60","0.46","","","" 10107653488973,51760714973517,"100 mg NAD (β-nicotinamide adenine dinucleotide oxidized form; CAS 53-84-9) – 1 vial of lyophilisate for reconstitution to 10 ml – Returns excluded – Imported product","AFEGA Research Group","China-Import","AFEGA® und UTHEVER® > Alle Produkte > ampullen > Bestseller > billiger > BLOG / Forschung > Energie & Stoffwechsel > Gedächtnis Fokus & "Senioren-Gehirn" > META-SALES Sortiment > NAD (Lyophilisate) > NAD+ > Regeneration & Zellschutz > Vorsorge","AFEGA-NAD-100","637962701739","https://www.afega.shop/cdn/shop/files/afega-nad-ampulle.webp?v=1775311913&width=1000","https://www.afega.shop/en/products/250-mg-nad-infusion-%CE%B2-nicotinamidadenindinukleotid-cas-53-84-9-ruckgabe-ausgeschlossen-importware-kopie?variant=51760714973517&utm_source=web&utm_medium=cpc&utm_campaign=billiger","in stock",44.12,428,6.50,15,"3-4 Tage","0.018 kg","100 mg NAD+-Infusion (β-Nicotinamidadenindinukleotid; CAS 53-84-9) - Rückgabe ausgeschlossen! Staffelpreise! Bei Außentemperaturen von mehr als 18 Grad wird Gekühlter Versand empfohlen! (Link anklicken und zur Bestellung hinzufügen!) Importware - Staffelpreise","1 vial of lyophilisate for reconstitution to 10 ml : This vial contains a freeze-dried powder (lyophilisate). Before use it must be reconstituted (i.e. dissolved) with a solvent (e.g. sterile water).We strongly recommend our blog post on NAD infusions.The quality of the product is regularly checked by the AFEGA Research Group!Minimum shelf life: All infusions we distribute are stable for at least 1 year from the date of sale without loss of quality when stored properly (protected from light 2° to 8°).Tiered prices at the bottom of this page.Minimum shelf life: 1 year when stored cool (2 - 8 degrees) dry and protected from light! For outside temperatures above 18 °C refrigerated shipping is recommended. Click the link to add it to your order.*** Delivery to addresses outside the EU ***If the delivery address is outside the EU you bear the risk if there are import issues in your country. Therefore do not order without ensuring that you are allowed to import these infusions! For deliveries outside the EU we ship exclusively via express due to the need for cooling. Please select the appropriate shipping option at checkout!Please note: This product is excluded from the right of return due to special delivery requirements!Advantages of lyophilized (freeze-dried) NAD+ powder compared to other formsStability and shelf lifeLyophilised NAD+ powder is particularly stable and has a longshelf life because of the freeze-drying process. The removal of water protects the sensitive molecule from degradation by hydrolysis or microbial contamination which is a common problem in liquid solutions. This allows NAD+ powder to be stored for longer periods without significant loss of NAD+.Purity and dosing accuracy This lyophilised NAD+ is offered in pharmaceutical -grade or laboratory-grade quality. The powder can be precisely dosed and flexibly used for various applications (e.g. infusions injections cell culture). Compared to tablets or capsules which often contain fillers and excipients the powder offers a higher concentration of active ingredient and fewer impurities.Flexibility in use The powder can be reconstituted as needed for example with sterile saline for infusions or other suitable solvents for research purposes. This allows the concentration and method of administration to be adjusted individually which is not possible with premixed solutions or solid dosage forms.Transport and storage Lyophilized powder is lighter and more space-saving to transport than liquid preparations. It does not require a continuous cold chain as long as it is stored dry and protected from light simplifying logistics and saving costs.Lower risk of chemical degradation In the dry state NAD+ is significantly less susceptible to oxidation and other chemical degradation processes than in solution ensuring quality until use.Sources:[1] https://ch.iherb.com/blog/nad-nmn-aging-benefits/1640[2] https://www.zentrum-der-gesundheit.de/ernaehrung/nahrungsergaenzung/weitere-nahrungsergaenzungsmittel/nad[3] https://www.orthoknowledge.eu/artikel/nad-und-alterung[4] https://www.krebsinformationsdienst.de/fachkreise/nachrichten/detail/nahrungsergaenzungsmittel-nadh-gegen-krebs[5] https://www.gesundheits-lexikon.com/Anti-Aging-Medizin/Schluesselgene-und-Signalwege-in-der-Anti-Aging-Forschung/NAD-und-sein-Einfluss-auf-das-Altern[6] https://www.klartext-nahrungsergaenzung.de/faq/projekt-klartext-nem/nad-und-nmn-in-nahrungsergaenzungsmitteln-38606[7] https://www.ganzimmun.de/fileadmin/user_upload/NAD_LIN0062_001.pdf******NAD+ (nicotinamide adenine dinucleotide) is an essential coenzyme found in every cell of the body and plays a central role in energy metabolism and cellular repair mechanisms. NAD+ levels in the body decrease with age which is associated with a variety of age-related health problems. NAD+ infusions where NAD+ is administered directly into the bloodstream have gained popularity in recent years. The following outlines the current state of scientific research on the benefits and risks of this therapy.Potential benefits of NAD+ infusions1. Support for cellular metabolism and energy productionNAD+ plays a central role in energy metabolism particularly in mitochondrial function ; mitochondriaare the cells’ “powerhouses”. Studies show that increasing NAD+ levels can improve mitochondrial function and promote cell health. (Verdin et al. Cell Metabolism 2015)2. Improvement of DNA repair and cellular stress responseNAD+ activates sirtuins and PARPs (poly-ADP-ribose polymerases) enzymes involved in DNA repair and regulation of cell stress. Higher NAD+ levels can therefore help reduce cell damage caused by aging and environmental factors. (Imai & Guarente Nature Reviews Molecular Cell Biology 2014)3. Neurological healthNAD+ is associated with neuronal function and the repair of neurological damage. Preliminary studies suggest that NAD+ infusions may be beneficial in neurodegenerative diseases such as Parkinsons and Alzheimers. (Braidy et al. Frontiers in Aging Neuroscience 2019)4. Support in addiction disordersSome clinical reports suggest that NAD+ infusions can help alleviate withdrawal symptoms and stabilize brain chemistry in people with alcohol or drug dependence. (Ross et al. Journal of Substance Use 2018)5. Anti-ageing effectsLower NAD+ levels are associated with signs of ageing and chronic diseases. Animal studies show that increasing NAD+ levels can promote longevity. (Yoshino et al. Cell Metabolism 2018)Risks and side effects of NAD+ infusions1. Insufficient long-term studiesAlthough NAD+ infusions have shown positive results in pilot studies comprehensive long-term studies on safety and efficacy in humans are currently lacking.2. Acute side effectsSome patients have reported symptoms such as nausea headaches hot flashes and dizziness during or after NAD+ infusions. These side effects appear to be dose-dependent. (Bogan & Brenner Annual Review of Nutrition 2008)3. Possible effects on metabolismAn increased NAD+ level could theoretically affect the balance of other metabolic pathways. This could be problematic especially for people with metabolic disorders such as diabetes or certain cancers.4. Cost and accessibilityNAD+ infusions are expensive and are not currently included in established clinical guidelines. They may therefore be considered experimental therapy.5. Infusion-related risksAs with any intravenous therapy there is a small risk of infections thrombosis or allergic reactions.ConclusionNAD+ infusions show promise for supporting cellular health particularly in age-related conditions and certain neurological and metabolic disorders. However their use remains experimental.Sources:[1] https://www.medrxiv.org/content/10.1101/2024.06.06.24308565v1.full[2] https://vitalivtherapy.com.au/studies-on-the-benefits-of-nad/[3] https://biorestorehealth.com/newtown-connecticut/what-is-nad-iv-therapy-process-benefits-and-risks/[4] https://aestha.co.uk/nad-iv-drip/[5] https://pmc.ncbi.nlm.nih.gov/articles/PMC9512238/[6] https://www.azivmedics.com/side-effects-of-nad-therapy[7] https://www.impnaples.com/post/the-science-behind-nad-iv-therapy-benefits-risks-and-effectivenessWhy are infusions so expensive?Members of our research group use this powder to make infusions for their personal use. For us this is acceptable because we are relying on our own judgement ourselvesregarding purity and in particular the absence of microbial contamination. However if you professionally offer NAD infusions you have a special responsibility towards your patients/customers and therefore need a particularly high level of safety. Legally required extensive documentation by manufacturers is intended to provide this high level of assurance. These infusions are expensive not because the substance is purer or more effective but because extensive documentation requirements —under which every batch must be fully traceable from NAD productionto the final product—are intended to assure a high level of purity.Here is a doctor’s guide to administering an infusion.Tiered pricesFrom 10 vials (one box): 10% – discount code at checkout: NAD-100-10 (delivery time in Switzerland: 4–5 weeks) From 20 vials (2 boxes of 10): 15% – discount code at checkout: NAD-100-20 (delivery time in Switzerland: 4–5 weeks) From 30 vials (3 boxes of 10): 20% – discount code at checkout: NAD-100-30 (delivery time in Switzerland: 4–5 weeks)From 50 vials (5 boxes of 10): 25% – discount code at checkout: NAD-100-50 (delivery time in Switzerland: 4–5 weeks)TRANSLATE with x EnglishArabicHebrewPolishBulgarianHindiPortugueseCatalanHmong DawRomanianChinese SimplifiedHungarianRussianChinese TraditionalIndonesianSlovakCzechItalianSlovenianDanishJapaneseSpanishDutchKlingonSwedishEnglishKoreanThaiEstonianLatvianTurkishFinnishLithuanianUkrainianFrenchMalayUrduGermanMalteseVietnameseGreekNorwegianWelshHaitian CreolePersian TRANSLATE with COPY THE URL BELOW Back EMBED THE SNIPPET BELOW IN YOUR SITE Enable collaborative features and customize widget: Bing Webmaster PortalBack","mg","100","","","0.44","" 9885500997965,50736719692109,"Liposomal Coenzyme AFEGA® Q10 Powder - 15 g pure powder (Unbeatable price-performance ratio)","Xi'an Natural Fields China","NF-LIP","AFEGA® und UTHEVER® > Alle Produkte > BLOG / Forschung > Coenzym Q10 / Ubiquinol > Erschöpfung & Muskelschwäche > Herz & Gefäße > META-SALES Sortiment","XI-Q10-10","637962701579","https://www.afega.shop/cdn/shop/files/afega-liposomales-q10-weisse-dose.webp?v=1775345835&width=1000","https://www.afega.shop/en/products/liposomales-coenzym-afega-q10-pulver-15-g-reines-pulver-unschlagbares-preis-wirkungs-verhltnis?variant=50736719692109&utm_source=web&utm_medium=cpc&utm_campaign=billiger","in stock",27.31,16,6.50,15,"3-4 Tage","0.02 kg","Liposomales Coenzym Q10-Pulver - 15 g reines PulverIm Kühlschrank lagern aber nicht tiefgefrieren (Substanzen mit einem Liposom dürfen nicht tiefgefroren werden.)Zusammensetzung:70% Q1015% Dextrin15% Phospholipids(Verzehrempfehlung: 143 mg entsprechend 100 mg Q10)Ein Dosierlöffel wird mitgeliefert aber es wird empfohlen diese preiswerte Digitalwaage mit zu bestellen","Coenzym Q10 (Ubiquinon) ist ein körpereigener Stoff der in Ihren Zellen an der Energiebereitstellung beteiligt ist. Man kann sich Q10 wie ein kleines „Zwischenstück“ im Zell-Kraftwerk vorstellen: Es hilft dabei Energieprozesse stabil am Laufen zu halten – besonders dort wo Gewebe dauerhaft Leistung braucht.Warum liposomal?Q10 ist von Natur aus fettlöslich. In liposomaler Form ist es in winzige Lipidträger eingebettet. Praktisch bedeutet das: Das Q10 ist geschützt und lässt sich in der täglichen Routine einfacher einbinden – insbesondere wenn Sie Wert auf eine moderne Trägerform legen.Warum als Pulver?Dieses Pulver enthält dieselbe liposomale Q10-Formulierung die auch in unseren Kapseln verwendet wird – nur als flexible Vorratsform. Das ist ideal wenn Sie:Ihre Tagesmenge frei anpassen möchten Q10 in eigene Routinen (z. B. Shake Joghurt Getränk) integrieren möchten oder eine Vorratsgröße bevorzugen.Was Sie konkret bekommenDarreichungsform: liposomales Coenzym Q10 als PulverNettofüllmenge: 15 gVerzehrempfehlungIn der Praxis wird Q10 häufig im Bereich von 50–200 mg pro Tag eingesetzt. Wenn Sie neu starten ist 100 mg täglich ein pragmatischer Einstiegspunkt den viele gut in den Alltag integrieren können.Anwendungstipp: Nehmen Sie Q10 idealerweise zu einer Mahlzeit ein. Das Pulver lässt sich gut in eine kleine Portion einrühren (z. B. Joghurt Shake oder ein Getränk). Bitte nicht stark erhitzen.Für wen ist Q10 besonders naheliegend?Alltag & Belastbarkeit: als klassischer Baustein rund um die Zellenergie-RoutineSport & Aktivität: wenn Training/Bewegung regelmäßig dazugehörtMit zunehmendem Alter: wenn Q10 als Zellenergie-Baustein sinnvoll in die persönliche Routine passtNahrungsergänzungsmittel sind kein Ersatz für eine ausgewogene Ernährung und eine gesunde Lebensweise.","g","15","","1.82","","" 10608962928973,53659781955917,"(More) Effective alternative to NMN: UthPeak®/AFEGA® (NMNH instead of NMN) - 60 capsules of 200 mg each","Effepharm China","AFEGA-KAPSELN","AFEGA® und UTHEVER® > Alle Produkte > billiger > BLOG / Forschung > Energie & Stoffwechsel > Gedächtnis Fokus & "Senioren-Gehirn" > Herz & Gefäße > META-SALES Sortiment > NMN > Regeneration & Zellschutz > Schlaf & innere Ruhe > Schlaf & innere Ruhe > Vorsorge","NMNH-60","0653748715158","https://www.afega.shop/cdn/shop/files/uthpeak-nmnh-kapseln-braunglas.webp?v=1775334842&width=1000","https://www.afega.shop/en/products/nmnh-uthpeak-50-kapseln-200-mg?variant=53659781955917&utm_source=web&utm_medium=cpc&utm_campaign=billiger","in stock",83.95,3,6.50,15,"3-4 Tage","0.1 kg","12 g NMNH (wirksamere Alternative zu NMN) - 60 Kapseln zu je 200 mg in luftdicht versiegeltem BraunglasIm Kühlschrank lagern und nach Anbruch innerhalb von 3 Monaten verbrauchen.","12 g NMNH (instead of NMN) - 60 capsules of 200 mg each Store in the refrigerator and use within 3 months. NMNH is supplied in capsules that are individually airtight packed. NMNH is stable at room temperature for at least 5 months but should still be stored in the refrigerator as a precaution. We will additionally protect the box with the capsules by packing it in a cool box if temperatures of more than 22 degrees can be reached during the day in Germany or the recipient country. If the product is still in the experimental phase can there be any danger from taking it? The following information is sometimes very demanding and requires special scientific knowledge. Since this is a new development there are no descriptions or YouTube videos aimed at laypeople. As soon as clear and easier-to-understand information becomes available we will revise this product description accordingly. ","capsule","60","1.4","","","" 10779143340365,54404009853261,"AFEGA® GHK-Cu-Creme 0 2 % – Kupferpeptid-Creme 50 ml","AFEGA Research Group","AFEGA Kosmetik","AFEGA® und UTHEVER® > Alle Produkte > Bestseller > billiger > BLOG / Forschung > Kosmetik > META-SALES Sortiment > Neuheiten > Sonderangebote > Vitamine / Peptide / Zellintelligenz","K-GHK-50-NEU","653748715189","https://www.afega.shop/cdn/shop/files/creme-anti-aging-weisse-dose.webp?v=1784739586&width=1000","https://www.afega.shop/en/products/afega-ghk-cu-creme-0-2-kupferpeptid-creme-50-ml?variant=54404009853261&utm_source=web&utm_medium=cpc&utm_campaign=billiger","in stock",49.58,16,6.50,15,"3-4 Tage","0.125 kg","Unsere AFEGA® GHK-Cu-Creme enthält das bewährte Kupfertripeptid GHK-Cu in einer sorgfältig stabilisierten Formulierung. Sie unterstützt die Hautregeneration fördert die Kollagenbildung und verbessert nachweislich die Hautelastizität – ohne künstliche Liposomen sondern in einer hautphysiologisch optimierten Rezeptur.","Anti-Aging auf molekularer Ebene: Unsere AFEGA® GHK-Cu-Creme enthält das bewährte Kupfertripeptid GHK-Cu in einer sorgfältig stabilisierten Formulierung. Sie unterstützt die Hautregeneration fördert die Kollagenbildung und verbessert nachweislich die Hautelastizität – ohne künstliche Liposomen sondern in einer hautphysiologisch optimierten Rezeptur.Wirkstoff: 2 mg GHK-Cu pro  ml CremebasisZusatzstoffe: Hyaluronsäure Vitamin E Niacinamid PanthenolpH-Wert: 5 2 – ideal für die Stabilität des Peptids und die HautKonservierung: mit Euxyl® PE 9010 – hautfreundlich & effektivVerpackung: Airless-Spender – schützt vor Oxidation & VerunreinigungGeeignet für alle Hauttypen – insbesondere bei ersten Fältchen regenerationsbedürftiger oder UV-geschädigter Haut.Anwendung: 1–2 Mal täglich auf die gereinigte Haut auftragen. Ideal auch als Nachtpflege oder punktuell bei Bedarf.Wissenschaftlich fundiert. Ohne PEGs Parabene oder synthetische Duftstoffe. Entwickelt nach AFEGA® Prinzipien – reduziert resonanzorientiert wirksam.INCI – Inhaltsstoffe (vollständig)Aqua Glycerin Dicaprylyl Carbonate Cetearyl Alcohol Glyceryl Stearate Citrate Tocopheryl Acetate Myristyl Myristate Stearic Acid Squalane Simmondsia Chinensis (Jojoba) Seed Oil Linum Usitatissimum (Flax) Seed Oil Allantoin Carbomer Panthenol GHK-Cu Niacinamide Ascorbic Acid Sodium Hydroxide Phenoxyethanol Ethylhexylglycerin.ProduktdetailsProduktart: Kosmetisches HautpflegeproduktDarreichungsform: CremeInhalt: 50 ml (Airless-Spender)Haltbarkeit: 12 Monate ungeöffnet 6 Monate nach AnbruchVerpackung: Airless-Spender lichtgeschütztHergestellt in: SchweizVertrieb: AFEGA Research GroupSicherheits- & AnwendungshinweiseNur zur äußeren Anwendung. Kontakt mit Augen vermeiden.Bei Reizungen Anwendung abbrechen und Hautarzt konsultieren.Kühl trocken und lichtgeschützt lagern (idealerweise Kühlschrank).Von Kindern fernhalten.BesonderheitenFrei von Parabenen Silikonen PEGs und synthetischen DuftstoffenTierversuchsfrei gemäß EU-KosmetikverordnungpH-optimierte Formulierung (ca. 5 2)Konserviert mit hautfreundlichem Euxyl® PE 9010TRANSLATE with x EnglishArabicHebrewPolishBulgarianHindiPortugueseCatalanHmong DawRomanianChinese SimplifiedHungarianRussianChinese TraditionalIndonesianSlovakCzechItalianSlovenianDanishJapaneseSpanishDutchKlingonSwedishEnglishKoreanThaiEstonianLatvianTurkishFinnishLithuanianUkrainianFrenchMalayUrduGermanMalteseVietnameseGreekNorwegianWelshHaitian CreolePersian TRANSLATE with COPY THE URL BELOW Back EMBED THE SNIPPET BELOW IN YOUR SITE Enable collaborative features and customize widget: Bing Webmaster PortalBack","g","50","","0.99","","" 9885701472589,50737387864397,"AFEGA® Brainfit * - Prophylaxis (40+) against forgetfulness and declining verbal competence","AFEGA Research Group","AFEGA-MIX","AFEGA® und UTHEVER® > AFEGA®-Rezepturen > Alle Produkte > BLOG / Forschung > Formulations > Gedächtnis Fokus & "Senioren-Gehirn" > Gedächtnis Fokus & „Senioren-Gehirn” > META-SALES Sortiment","AFEGA-R1-60-*","637962701418","https://www.afega.shop/cdn/shop/files/afega-brainfit-kapseln-weisse-Dose.webp?v=1775335110&width=1000","https://www.afega.shop/en/products/afega%C2%AE-brainfit-prophylaxe-40-gegen-vergesslichkeit-und-nachlassende-verbale-kompetenz-copy?variant=50737387864397&utm_source=web&utm_medium=cpc&utm_campaign=billiger","in stock",46.13,25,6.50,15,"3-4 days","0.045 kg","AFEGA® Brainfit* Rezeptur 120 Kapseln zu je 500 mg (Monatsration)Im Kühlschrank aufbewahrenUnbedingt die Produktbeschreibung lesen!","Bitte zunächst diese Einführung lesen! Die kognitive Funktion und Gedächtnisleistung sind zentrale Aspekte der menschlichen Lebensqualität. Mit dem Alter und durch Stressfaktoren kann die kognitive Leistungsfähigkeit abnehmen. Natürliche Substanzen die nachweislich die Gehirnfunktion unterstützen bieten eine vielversprechende Möglichkeit diesem Verfall entgegenzuwirken. Stellen Sie sich vor Sie könnten Ihre geistige Leistungsfähigkeit durch eine sorgfältig zusammengestellte Mischung natürlicher Substanzen verbessern. Wir präsentieren Ihnen unseren ultimativen Gedächtnis-Cocktail basierend auf den neuesten wissenschaftlichen Erkenntnissen ergänzt um 3 Produkte aus dem Bereich der Homöopathie (Anacardium orientale Lycopodium und Kali Phosphoricum). Anwendung und Dosierung Die empfohlene tägliche Mindestdosis unseres Gedächtnis-Cocktails beträgt etwa 2 Gramm (4 Kapseln) was alle notwendigen Nährstoffe in den optimalen Mengenanteiln liefert um Ihre geistige Leistungsfähigkeit zu maximieren. Diese Dosis kann ohne die geringste Gefahr einer Überdosierung mindestens auf das 3fache gesteigert werden um eine schnellere und intensivere Wirkung zu erzielen. In der folgenden Liste der Inhaltsstoffe fehlen zwei wichtige Substanzen: NMN und ResveratrolNMN haben wir aus zwei Gründen nicht in den Cocktail integriert: Der wichtigste Grund ist dass Sie NMN sublingual applizieren sollten es also unter der Zunge zergehen lassen (zur Begründung siehe diese Studie). Darüber hinaus gehen wir davon aus dass die meisten unserer Kunden wegen der beeindruckenden Anti-Aging-Eigenschaften ohnehin NMN supplementieren und dann würde es keinen Sinn machen die Rezeptur durch Zugabe von NMN unnötig zu verteuern. Letzterer Grund gilt auch für Resveratrol. Also bitte beachten: NMN und Resveratrol sind wichtige Bestandteile dieser Rezeptur müssen aber gesondert bestellt werden (wir empfehlen 450 mg liposomales NMN und 500 mg mikronisierte Resveratrol pro Tag).Wissenschaftliche Basis und SicherheitUnsere Mischung basiert auf sorgfältiger Forschung und wissenschaftlicher Evidenz. Jede Komponente wurde aufgrund ihrer nachgewiesenen Vorteile für die kognitive Gesundheit ausgewählt und in optimalen Mengenanteilen kombiniert um synergistische Effekte zu erzielen. Omega-3-Fettsäuren (DHA und EPA) Omega-3-Fettsäuren insbesondere DHA (Docosahexaensäure) und EPA (Eicosapentaensäure) spielen eine wesentliche Rolle bei der Aufrechterhaltung der neuronalen Integrität und Funktion. Diese Fettsäuren sind wichtige Bestandteile der Zellmembranen im Gehirn und fördern die Fluidität und Signalübertragung zwischen Neuronen. Mengenanteil: 33 3 % Studienbelege: - Eine systematische Überprüfung und Meta-Analyse von Suh und Lim (2018) zeigt dass die Einnahme von Omega-3-Fettsäuren signifikant mit einer Verbesserung der kognitiven Funktionen und einer Verringerung des Risikos für neurodegenerative Erkrankungen verbunden ist. - Eine weitere Studie von Spencer et al. (2023) fand heraus dass höhere Blutspiegel von Omega-3-Fettsäuren mit besserer Gedächtnisleistung und größeren Gehirnvolumina bei älteren Erwachsenen korrelieren. Ginkgo Biloba Ginkgo Biloba ist ein pflanzlicher Extrakt der traditionell zur Verbesserung der Durchblutung und kognitiven Funktionen verwendet wird. Es wird angenommen dass die aktiven Bestandteile wie Flavonoide und Terpenoide neuroprotektive Eigenschaften besitzen. Mengenanteil: 3 3 % Studienbelege: - Eine systematische Übersichtsarbeit zeigt dass Ginkgo Biloba bei älteren Erwachsenen mit kognitiven Beeinträchtigungen die Gedächtnisleistung und die Fähigkeit zur Problemlösung verbessert. - Studien von Lekomtseva et al. (2017) belegen dass Ginkgo Biloba die kognitive Funktion und die Stimmung bei Patienten mit chronischer Müdigkeit signifikant verbessert. Vitamin B-Komplex Die Vitamine des B-Komplexes insbesondere B6 B12 und Folsäure sind für die Synthese von Neurotransmittern und die Aufrechterhaltung der neuronalen Gesundheit unerlässlich. Diese Vitamine unterstützen den Energiestoffwechsel im Gehirn und fördern die kognitive Leistungsfähigkeit. Mengenanteil: 16 7 % Studienbelege: - Eine Metaanalyse von Oulhaj et al. (2020) zeigt dass die Ergänzung mit Vitamin B-Komplexen die Hirnatrophie bei Menschen mit leichten kognitiven Beeinträchtigungen verlangsamt. - Eine Studie von Smith et al. (2010) fand heraus dass die tägliche Einnahme von B-Vitaminen die kognitive Leistung bei älteren Erwachsenen verbessert und das Risiko für Alzheimer reduziert. Phosphatidylserin Phosphatidylserin ist ein Phospholipid das eine Schlüsselrolle in der Struktur und Funktion der Zellmembranen spielt. Es unterstützt die Signalübertragung zwischen Neuronen und die Freisetzung von Neurotransmittern die für das Gedächtnis und die kognitive Funktion wichtig sind. Mengenanteil: 16 7 % Studienbelege: - Eine Studie von Glade und Smith (2015) zeigt dass die Ergänzung mit Phosphatidylserin die Gedächtnisleistung und das Lernvermögen bei älteren Erwachsenen signifikant verbessert. - Eine Meta-Analyse mehrerer Studien bestätigt dass Phosphatidylserin die kognitive Funktion durch die Unterstützung der neuronalen Kommunikation und Membranintegrität verbessert. L-Theanin L-Theanin ist eine Aminosäure die hauptsächlich in grünem Tee vorkommt. Es hat entspannende und angstlösende Eigenschaften die ohne sedative Effekte die kognitive Funktion und Aufmerksamkeit verbessern können. Mengenanteil: 6 7 % Studienbelege: - Eine Studie von White et al. (2016) zeigt dass L-Theanin die Aufmerksamkeit und kognitive Leistung in stressigen Situationen verbessert. - Eine andere Untersuchung von Haskell et al. (2008) fand heraus dass L-Theanin in Kombination mit Koffein die geistige Klarheit und Reaktionszeit verbessert. Coenzym Q10 (CoQ10) Coenzym Q10 ist ein Antioxidans das für die Energieproduktion in den Mitochondrien unerlässlich ist. Es schützt die Gehirnzellen vor oxidativem Stress und unterstützt die neuronale Funktion. Mengenanteil 6 7 % Studienbelege: - Eine Studie von Shults et al. (2002) zeigt dass CoQ10 die kognitive Funktion bei Patienten mit neurodegenerativen Erkrankungen verbessert. - Eine weitere Untersuchung von Beal (1999) bestätigt dass CoQ10 neuroprotektive Eigenschaften hat und die kognitive Leistung unterstützt. - Siehe die ausführliche anschauliche Darstellung des Forschungsstandes zu Q10 in unserer Shop-Kategorie Q10 Rhodiola Rosea / Fructus Ligustris (Wirkstoff: Salidroside) Rhodiola Rosea ist ein Adaptogen das die Widerstandsfähigkeit gegen Stress erhöht und die kognitive Funktion verbessert. Es wird traditionell zur Steigerung der geistigen Leistungsfähigkeit und zur Reduzierung von Müdigkeit verwendet. Mengenanteil: 16 7 % Studienbelege: - Eine Meta-Analyse von Ma et al. (2018) zeigt dass Rhodiola Rosea die Lern- und Gedächtnisfunktion durch die Erhöhung der neuronalen Erregbarkeit und die Verbesserung der Stressresistenz signifikant verbessert. - Eine weitere Studie von Zwaka et al. (2018) bestätigt dass Rhodiola Rosea die Gedächtnisleistung bei verschiedenen Tiermodellen und potenziell auch bei Menschen verbessert. Quellen:- Suh S.W. & Lim E. (2018). The influence of n-3 polyunsaturated fatty acids on cognitive function in individuals without dementia: a systematic review and dose–response meta-analysis. *BMC Medicine*. (https://bmcmedicine.biomedcentral.com/articles/10.1186/s12916-018-1237-9) - Glade M.J. & Smith K. (2015). Phosphatidylserine and the human brain. *Nutrition Reviews*. (https://academic.oup.com/nutritionreviews/article/73/4/280/1931114) - Harvard Magazine. (2018). A New Plant to Enhance Memory. (https://www.harvardmagazine.com/2018/10/rhodiola-rosea-memory-enhancer) - Frontiers in Pharmacology. (2020). Rhodiola rosea L. Improves Learning and Memory Function: Preclinical Evidence and Possible Mechanisms. (https://www.frontiersin.org/articles/10.3389/fphar.2020.01415/full) Omega3: https://academic.oup.com/nutritionreviews/article/76/1/1/4732611#:~:text=URL%3A%20https%3A%2F%2Facademic.oup.com%2Fnutritionreviews%2Farticle%2F76%2F1%2F1%2F4732611%0ALoading...%0AVisible%3A%200%25%20 https://www.mdpi.com/2076-3425/13/9/1278 https://bmjopen.bmj.com/content/9/6/e027167 Ginko: https://pubmed.ncbi.nlm.nih.gov/19160216/ https://jamanetwork.com/journals/jamaneurology/fullarticle/774397 Vitamin B-Komplex: https://pubmed.ncbi.nlm.nih.gov/20838622/#:~:text=Conclusions%20and%20significance%3A%20The%20accelerated of%20these%20develop%20Alzheimers%20disease. https://www.sciencedirect.com/science/article/abs/pii/S0197457223000526#:~:text=Conclusions the%20decline%20in%20cognitive%20function. Phosphatidylserin: https://www.frontiersin.org/journals/aging-neuroscience/articles/10.3389/fnagi.2022.975176/full L-Theanin: https://pubmed.ncbi.nlm.nih.gov/18296328/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8080935/ Rhodiola Rosea / Fructus Ligustris (Wirkstoff: Salidroside): https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2018.01415/full https://link.springer.com/article/10.1007/s12210-022-01055-y https://www.harvardmagazine.com/2018/10/rhodiola-rosea-memory-loss -------------------- Informationen zu möglichen Nebenwirkungen:Wichtige Hinweise für Patienten mit Bluthochdruck Gefäßverengungen und blutdrucksenkenden Medikamenten.Mögliche Wechselwirkungen:- Erhöhtes Blutungsrisiko: Kombination von Omega-3-Fettsäuren und Ginkgo Biloba kann das Blutungsrisiko leicht erhöhen besonders bei gleichzeitiger Einnahme von Blutverdünnern (z.B. ASS Clopidogrel Warfarin).- Blutdrucksenkende Effekte: Leichte Verstärkung der Wirkung von blutdrucksenkenden Medikamenten möglich durch Omega-3 L-Theanin CoQ10 und Ginkgo Biloba.- Gefäßverengungen (z.B. Arteriosklerose): Ginkgo Biloba kann die Durchblutung beeinflussen und in seltenen Fällen Blutdruckschwankungen verursachen.Vorsicht vor Operationen:Setzen Sie Brainfit mindestens 1 Woche vor geplanten Operationen ab um Blutungsrisiken zu minimieren (nur nach Absprache mit Ihrem Arzt).Wichtiger Hinweis: Diese Informationen ersetzen nicht die Beratung durch Ihren Arzt oder Apotheker. Bitte sprechen Sie bei Unsicherheiten immer mit einem medizinischen Fachpersonal. ","capsule","120","0.38","","","" 9885501260109,50736719954253,"AFEGA® Brainfit - Prophylaxis (40+) against forgetfulness and declining verbal competence","AFEGA Research Group","AFEGA-MIX","AFEGA® und UTHEVER® > AFEGA®-Rezepturen > Alle Produkte > BLOG / Forschung > Formulations > Gedächtnis Fokus & "Senioren-Gehirn" > Gedächtnis Fokus & „Senioren-Gehirn” > META-SALES Sortiment","AFEGA-R1-60","637962701548","https://www.afega.shop/cdn/shop/files/afega-brainfit-kapseln-in-weisser-dose.webp?v=1775345270&width=1000","https://www.afega.shop/en/products/afega-brainfit-prophylaxe-40-gegen-vergesslichkeit-und-nachlassende-verbale-kompetenz?variant=50736719954253&utm_source=web&utm_medium=cpc&utm_campaign=billiger","in stock",44.12,23,6.50,15,"3-4 Tage","0.045 kg","AFEGA® Brainfit Rezeptur 120 Kapseln zu je 500 mg (Monatsration)Im Kühlschrank aufbewahrenUnbedingt die Produktbeschreibung lesen!","Bitte zunächst diese Einführung lesen! Die kognitive Funktion und Gedächtnisleistung sind zentrale Aspekte der menschlichen Lebensqualität. Mit dem Alter und durch Stressfaktoren kann die kognitive Leistungsfähigkeit abnehmen. Natürliche Substanzen die nachweislich die Gehirnfunktion unterstützen bieten eine vielversprechende Möglichkeit diesem Verfall entgegenzuwirken. Stellen Sie sich vor Sie könnten Ihre geistige Leistungsfähigkeit durch eine sorgfältig zusammengestellte Mischung natürlicher Substanzen verbessern. Wir präsentieren Ihnen unseren ultimativen Gedächtnis-Cocktail basierend auf den neuesten wissenschaftlichen Erkenntnissen. Anwendung und Dosierung Die empfohlene tägliche Mindestdosis unseres Gedächtnis-Cocktails beträgt etwa 2 Gramm (4 Kapseln) was alle notwendigen Nährstoffe in den optimalen Mengenanteiln liefert um Ihre geistige Leistungsfähigkeit zu maximieren. Diese Dosis kann ohne die geringste Gefahr einer Überdosierung mindestens auf das 3fache gesteigert werden um eine schnellere und intensivere Wirkung zu erzielen. In der folgenden Liste der Inhaltsstoffe fehlen zwei wichtige Substanzen: NMN und ResveratrolNMN haben wir aus zwei Gründen nicht in den Cocktail integriert: Der wichtigste Grund ist dass Sie NMN sublingual applizieren sollten es also unter der Zunge zergehen lassen (zur Begründung siehe diese Studie). Darüber hinaus gehen wir davon aus dass die meisten unserer Kunden wegen der beeindruckenden Anti-Aging-Eigenschaften ohnehin NMN supplementieren und dann würde es keinen Sinn machen die Rezeptur durch Zugabe von NMN unnötig zu verteuern. Letzterer Grund gilt auch für Resveratrol. Also bitte beachten: NMN und Resveratrol sind wichtige Bestandteile dieser Rezeptur müssen aber gesondert bestellt werden (wir empfehlen 450 mg liposomales NMN und 500 mg mikronisierte Resveratrol pro Tag). Wissenschaftliche Basis und SicherheitUnsere Mischung basiert auf sorgfältiger Forschung und wissenschaftlicher Evidenz. Jede Komponente wurde aufgrund ihrer nachgewiesenen Vorteile für die kognitive Gesundheit ausgewählt und in optimalen Mengenanteilen kombiniert um synergistische Effekte zu erzielen. Omega-3-Fettsäuren (DHA und EPA) Omega-3-Fettsäuren insbesondere DHA (Docosahexaensäure) und EPA (Eicosapentaensäure) spielen eine wesentliche Rolle bei der Aufrechterhaltung der neuronalen Integrität und Funktion. Diese Fettsäuren sind wichtige Bestandteile der Zellmembranen im Gehirn und fördern die Fluidität und Signalübertragung zwischen Neuronen. Mengenanteil: 33 3 % Studienbelege: - Eine systematische Überprüfung und Meta-Analyse von Suh und Lim (2018) zeigt dass die Einnahme von Omega-3-Fettsäuren signifikant mit einer Verbesserung der kognitiven Funktionen und einer Verringerung des Risikos für neurodegenerative Erkrankungen verbunden ist. - Eine weitere Studie von Spencer et al. (2023) fand heraus dass höhere Blutspiegel von Omega-3-Fettsäuren mit besserer Gedächtnisleistung und größeren Gehirnvolumina bei älteren Erwachsenen korrelieren. Ginkgo Biloba Ginkgo Biloba ist ein pflanzlicher Extrakt der traditionell zur Verbesserung der Durchblutung und kognitiven Funktionen verwendet wird. Es wird angenommen dass die aktiven Bestandteile wie Flavonoide und Terpenoide neuroprotektive Eigenschaften besitzen. Mengenanteil: 3 3 % Studienbelege: - Eine systematische Übersichtsarbeit zeigt dass Ginkgo Biloba bei älteren Erwachsenen mit kognitiven Beeinträchtigungen die Gedächtnisleistung und die Fähigkeit zur Problemlösung verbessert. - Studien von Lekomtseva et al. (2017) belegen dass Ginkgo Biloba die kognitive Funktion und die Stimmung bei Patienten mit chronischer Müdigkeit signifikant verbessert. Vitamin B-Komplex Die Vitamine des B-Komplexes insbesondere B6 B12 und Folsäure sind für die Synthese von Neurotransmittern und die Aufrechterhaltung der neuronalen Gesundheit unerlässlich. Diese Vitamine unterstützen den Energiestoffwechsel im Gehirn und fördern die kognitive Leistungsfähigkeit. Mengenanteil: 16 7 % Studienbelege: - Eine Metaanalyse von Oulhaj et al. (2020) zeigt dass die Ergänzung mit Vitamin B-Komplexen die Hirnatrophie bei Menschen mit leichten kognitiven Beeinträchtigungen verlangsamt. - Eine Studie von Smith et al. (2010) fand heraus dass die tägliche Einnahme von B-Vitaminen die kognitive Leistung bei älteren Erwachsenen verbessert und das Risiko für Alzheimer reduziert. Phosphatidylserin Phosphatidylserin ist ein Phospholipid das eine Schlüsselrolle in der Struktur und Funktion der Zellmembranen spielt. Es unterstützt die Signalübertragung zwischen Neuronen und die Freisetzung von Neurotransmittern die für das Gedächtnis und die kognitive Funktion wichtig sind. Mengenanteil: 16 7 % Studienbelege: - Eine Studie von Glade und Smith (2015) zeigt dass die Ergänzung mit Phosphatidylserin die Gedächtnisleistung und das Lernvermögen bei älteren Erwachsenen signifikant verbessert. - Eine Meta-Analyse mehrerer Studien bestätigt dass Phosphatidylserin die kognitive Funktion durch die Unterstützung der neuronalen Kommunikation und Membranintegrität verbessert. L-Theanin L-Theanin ist eine Aminosäure die hauptsächlich in grünem Tee vorkommt. Es hat entspannende und angstlösende Eigenschaften die ohne sedative Effekte die kognitive Funktion und Aufmerksamkeit verbessern können. Mengenanteil: 6 7 % Studienbelege: - Eine Studie von White et al. (2016) zeigt dass L-Theanin die Aufmerksamkeit und kognitive Leistung in stressigen Situationen verbessert. - Eine andere Untersuchung von Haskell et al. (2008) fand heraus dass L-Theanin in Kombination mit Koffein die geistige Klarheit und Reaktionszeit verbessert. Coenzym Q10 (CoQ10) Coenzym Q10 ist ein Antioxidans das für die Energieproduktion in den Mitochondrien unerlässlich ist. Es schützt die Gehirnzellen vor oxidativem Stress und unterstützt die neuronale Funktion. Mengenanteil 6 7 % Studienbelege: - Eine Studie von Shults et al. (2002) zeigt dass CoQ10 die kognitive Funktion bei Patienten mit neurodegenerativen Erkrankungen verbessert. - Eine weitere Untersuchung von Beal (1999) bestätigt dass CoQ10 neuroprotektive Eigenschaften hat und die kognitive Leistung unterstützt. - Siehe die ausführliche anschauliche Darstellung des Forschungsstandes zu Q10 in unserer Shop-Kategorie Q10 Rhodiola Rosea / Fructus Ligustris (Wirkstoff: Salidroside) Rhodiola Rosea ist ein Adaptogen das die Widerstandsfähigkeit gegen Stress erhöht und die kognitive Funktion verbessert. Es wird traditionell zur Steigerung der geistigen Leistungsfähigkeit und zur Reduzierung von Müdigkeit verwendet. Mengenanteil: 16 7 % Studienbelege: - Eine Meta-Analyse von Ma et al. (2018) zeigt dass Rhodiola Rosea die Lern- und Gedächtnisfunktion durch die Erhöhung der neuronalen Erregbarkeit und die Verbesserung der Stressresistenz signifikant verbessert. - Eine weitere Studie von Zwaka et al. (2018) bestätigt dass Rhodiola Rosea die Gedächtnisleistung bei verschiedenen Tiermodellen und potenziell auch bei Menschen verbessert. Quellen:Suh S.W. & Lim E. (2018). The influence of n-3 polyunsaturated fatty acids on cognitive function in individuals without dementia: a systematic review and dose–response meta-analysis. *BMC Medicine*. (https://bmcmedicine.biomedcentral.com/articles/10.1186/s12916-018-1237-9) - Glade M.J. & Smith K. (2015). Phosphatidylserine and the human brain. *Nutrition Reviews*. (https://academic.oup.com/nutritionreviews/article/73/4/280/1931114) - Harvard Magazine. (2018). A New Plant to Enhance Memory. (https://www.harvardmagazine.com/2018/10/rhodiola-rosea-memory-enhancer) - Frontiers in Pharmacology. (2020). Rhodiola rosea L. Improves Learning and Memory Function: Preclinical Evidence and Possible Mechanisms. (https://www.frontiersin.org/articles/10.3389/fphar.2020.01415/full) Omega3: https://academic.oup.com/nutritionreviews/article/76/1/1/4732611#:~:text=URL%3A%20https%3A%2F%2Facademic.oup.com%2Fnutritionreviews%2Farticle%2F76%2F1%2F1%2F4732611%0ALoading...%0AVisible%3A%200%25%20 https://www.mdpi.com/2076-3425/13/9/1278 https://bmjopen.bmj.com/content/9/6/e027167 Ginko: https://pubmed.ncbi.nlm.nih.gov/19160216/ https://jamanetwork.com/journals/jamaneurology/fullarticle/774397 Vitamin B-Komplex: https://pubmed.ncbi.nlm.nih.gov/20838622/#:~:text=Conclusions%20and%20significance%3A%20The%20accelerated;of%20these%20develop%20Alzheimers%20disease. https://www.sciencedirect.com/science/article/abs/pii/S0197457223000526#:~:text=Conclusions;the%20decline%20in%20cognitive%20function. Phosphatidylserin: https://www.frontiersin.org/journals/aging-neuroscience/articles/10.3389/fnagi.2022.975176/full L-Theanin: https://pubmed.ncbi.nlm.nih.gov/18296328/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8080935/ Rhodiola Rosea / Fructus Ligustris (Wirkstoff: Salidroside): https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2018.01415/full https://link.springer.com/article/10.1007/s12210-022-01055-y https://www.harvardmagazine.com/2018/10/rhodiola-rosea-memory-loss ----------------  Informationen zu möglichen Nebenwirkungen:Wichtige Hinweise für Patienten mit Bluthochdruck Gefäßverengungen und blutdrucksenkenden Medikamenten.Mögliche Wechselwirkungen:- Erhöhtes Blutungsrisiko: Kombination von Omega-3-Fettsäuren und Ginkgo Biloba kann das Blutungsrisiko leicht erhöhen besonders bei gleichzeitiger Einnahme von Blutverdünnern (z.B. ASS Clopidogrel Warfarin).- Blutdrucksenkende Effekte: Leichte Verstärkung der Wirkung von blutdrucksenkenden Medikamenten möglich durch Omega-3 L-Theanin CoQ10 und Ginkgo Biloba.- Gefäßverengungen (z.B. Arteriosklerose): Ginkgo Biloba kann die Durchblutung beeinflussen und in seltenen Fällen Blutdruckschwankungen verursachen.Vorsicht vor Operationen:Setzen Sie Brainfit mindestens 1 Woche vor geplanten Operationen ab um Blutungsrisiken zu minimieren (nur nach Absprache mit Ihrem Arzt).Wichtiger Hinweis: Diese Informationen ersetzen nicht die Beratung durch Ihren Arzt oder Apotheker. Bitte sprechen Sie bei Unsicherheiten immer mit einem medizinischen Fachpersonal. ","capsule","120","0.37","","","" 10391334289741,52824136876365,"AFEGA® Epitalon Sublingual Tropfen (10 ml)","AFEGA Research Group","AFEGA-MIX","AFEGA® und UTHEVER® > Alle Produkte > BLOG / Forschung > Epitalon > Formulations > META-SALES Sortiment > Neuheiten > Regeneration & Zellschutz > Vitamine / Peptide / Zellintelligenz > Vorsorge","AFEGA-R4","0653748715035","https://www.afega.shop/cdn/shop/files/afega-epitalon-tropfen-braune-pipettenflasche.webp?v=1775249361&width=1000","https://www.afega.shop/en/products/epitalon-sublingual-tropfen?variant=52824136876365&utm_source=web&utm_medium=cpc&utm_campaign=billiger","in stock",66.39,4,6.50,15,"3-4 Tage","","Epitalon gilt seit langem als einer der vielversprechendsten Kandidaten in der Peptid-basierten Anti-Aging-Forschung. Ursprünglich durch den russischen Wissenschaftler Prof. Vladimir Khavinson entdeckt zeigt es in Studien bemerkenswerte Wirkungen auf die Telomer-Stabilisierung die Regulation der Melatoninproduktion und sogar auf die Lebensspanne von Modellorganismen.","Epitalon ist ein Peptid das mit bemerkenswerten Anti-Aging-Eigenschaften erforscht wurde. Die AFEGA®-Sublingual-Formulierung ermöglicht eine besonders effiziente Aufnahme über die Mundschleimhaut.Anwendung & DosierungInhalt: 10 ml Braunglasflasche mit Pipette Epitalon-Konzentration: 6 mg/ml Empfohlene Anwendung: 2× täglich 3–5 Tropfen sublingual (z. B. morgens & abends) 1 Tropfen enthält ca. 0 3 mg Epitalon → Tagesdosis: 1 8–3 0 mg EpitalonDie Tropfen unter die Zunge geben etwa 1 Minute dort halten und dann schlucken. Diese Art der Aufnahme umgeht weitgehend den Magen-Darm-Trakt und erlaubt eine schnelle Verwertung durch den Körper.AFEGA®-Wissenschaft im FokusEpitalon ist bekannt für seine potenziellen Effekte auf:die Telomer-Stabilisierung die Regulation des Schlaf-Wach-Rhythmus die allgemeine Zellregeneration.Unsere Formulierung ist frei von Alkohol und enthält keine künstlichen Aromen – ideal für eine sanfte und effiziente tägliche Anwendung.Zusammensetzung (pro 10 ml)Epitalon: 60 mgGlycerin (pflanzlich)Aqua purificataNaHCO3Ethanol (Konservierungsmittel)HinweiseAußerhalb der Reichweite von Kindern aufbewahrenKühl und lichtgeschützt lagernFür ErwachseneKein Arzneimittel – keine zugelassene medizinische IndikationHinweis: Dieses Produkt dient der wissenschaftlich fundierten Anti-Aging-Begleitung im Rahmen individueller Lebensgestaltung.TRANSLATE with x EnglishArabicHebrewPolishBulgarianHindiPortugueseCatalanHmong DawRomanianChinese SimplifiedHungarianRussianChinese TraditionalIndonesianSlovakCzechItalianSlovenianDanishJapaneseSpanishDutchKlingonSwedishEnglishKoreanThaiEstonianLatvianTurkishFinnishLithuanianUkrainianFrenchMalayUrduGermanMalteseVietnameseGreekNorwegianWelshHaitian CreolePersian TRANSLATE with COPY THE URL BELOW Back EMBED THE SNIPPET BELOW IN YOUR SITE Enable collaborative features and customize widget: Bing Webmaster PortalBack","ml","10","","","","6.64" 10084631675213,51664856416589,"500 mg NAD (β-nicotinamide adenine dinucleotide oxidized form; CAS 53-84-9) – 1 vial of lyophilisate for reconstitution to 10 ml – Returns excluded – EU product (EU-compliant manufacturing)","AFEGA Research Group","NAD+ Shop","AFEGA® und UTHEVER® > Alle Produkte > ampullen > BLOG / Forschung > Energie & Stoffwechsel > Gedächtnis Fokus & "Senioren-Gehirn" > META-SALES Sortiment > NAD (Lyophilisate) > NAD+ > Regeneration & Zellschutz > Vorsorge","AFEGA-NAD-500","637962701692","https://www.afega.shop/cdn/shop/files/afega-nad-ampulle-durchstechflasche.webp?v=1775317399&width=1000","https://www.afega.shop/en/products/250-mg-nad-%CE%B2-nicotinamidadenindinukleotid-cas-53-84-9-202505?variant=51664856416589&utm_source=web&utm_medium=cpc&utm_campaign=billiger","in stock",273.11,42,0,15,"1 bis 2 Wochen (für CH aktuell 2-3 Wochen)","0.05 kg","1 Inj. Fl. Trs. in einer 10 ml-Ampulle (Trs. = Trockensubstanz/Lyophilisat): Es handelt sich um ein Fläschchen das ein gefriergetrocknetes Pulver (Lyophilisat) enthält. Bei Außentemperaturen von mehr als 18 Grad wird Gekühlter Versand empfohlen! (Link anklicken und zur Bestellung hinzufügen!)","500 mg NAD (β-nicotinamide adenine dinucleotide oxidised form; CAS 53-84-9) – Returns excludedWe strongly recommend our blog post on NAD infusions.GUARANTEE: Manufactured in Europe in compliance with all relevant pharmaceutical and regulatory requirements.1 vial of lyophilisate for reconstitution to 10 ml : This vial contains a freeze-dried powder (lyophilisate). Before use it must be reconstituted (i.e. dissolved) with a solvent (e.g. sterile water).Minimum shelf life: All infusions we distribute are stable for at least 1 year from the date of sale without loss of quality when stored properly (protected from light 2° to 8°). For outside temperatures above 18 °C refrigerated shipping is recommended. Click the link to add it to your order.*** Delivery to addresses outside the EU ***If the delivery address is outside the EU you bear the risk if there are import issues in your country. Do not order before confirming that you are permitted to import these infusion products. For deliveries outside the EU we ship exclusively via express due to the need for cooling. Please select the appropriate shipping option at checkout!Please note: These infusion products are excluded from the right of return because of their special delivery requirements.Advantages of lyophilized (freeze-dried) NAD+ powder compared to other formsStability and shelf lifeLyophilised NAD+ powder is particularly stable and has a longshelf life because of the freeze-drying process. Removing water protects the sensitive molecule from degradation through hydrolysis or microbial contamination both of which are common problems with liquid solutions. This allows NAD+ powder to be stored for longer periods without significant loss of NAD+.Purity and dosing accuracy This lyophilised NAD+ is offered in pharmaceutical -grade or laboratory-grade quality. The powder can be precisely dosed and flexibly used for various applications (e.g. infusions injections cell culture). Compared to tablets or capsules which often contain fillers and excipients the powder offers a higher concentration of active ingredient and fewer impurities.Flexibility in use The powder can be reconstituted as needed for example with sterile saline for infusions or other suitable solvents for research purposes. This allows the concentration and method of administration to be adjusted individually which is not possible with premixed solutions or solid dosage forms.Transport and storage Lyophilized powder is lighter and more space-saving to transport than liquid preparations. It does not require a continuous cold chain as long as it is stored dry and protected from light simplifying logistics and saving costs.Lower risk of chemical degradation In its dry state NAD+ is significantly less susceptible to oxidation and other degradation processes than it is in solution helping to preserve quality until use.Sources:[1] https://ch.iherb.com/blog/nad-nmn-aging-benefits/1640[2] https://www.zentrum-der-gesundheit.de/ernaehrung/nahrungsergaenzung/weitere-nahrungsergaenzungsmittel/nad[3] https://www.orthoknowledge.eu/artikel/nad-und-alterung[4] https://www.krebsinformationsdienst.de/fachkreise/nachrichten/detail/nahrungsergaenzungsmittel-nadh-gegen-krebs[5] https://www.gesundheits-lexikon.com/Anti-Aging-Medizin/Schluesselgene-und-Signalwege-in-der-Anti-Aging-Forschung/NAD-und-sein-Einfluss-auf-das-Altern[6] https://www.klartext-nahrungsergaenzung.de/faq/projekt-klartext-nem/nad-und-nmn-in-nahrungsergaenzungsmitteln-38606[7] https://www.ganzimmun.de/fileadmin/user_upload/NAD_LIN0062_001.pdf******NAD+ (nicotinamide adenine dinucleotide) is an essential coenzyme found in every cell of the body and plays a central role in energy metabolism and cellular repair mechanisms. NAD+ levels in the body decline with age which is associated with a variety of age-related health problems. NAD+ infusions where NAD+ is administered directly into the bloodstream have gained popularity in recent years. The following outlines the current state of scientific research on the benefits and risks of this therapy.Potential benefits of NAD+ infusions1. Support for cellular metabolism and energy productionNAD+ plays a central role in energy metabolism particularly in mitochondrial function ; mitochondriaare the cells’ “powerhouses”. Studies show that increasing NAD+ levels can improve mitochondrial function and promote cell health. (Verdin et al. Cell Metabolism 2015)2. Improvement of DNA repair and cellular stress responseNAD+ activates sirtuins and PARPs (poly-ADP-ribose polymerases) enzymes involved in DNA repair and regulation of cell stress. Higher NAD+ levels can therefore help reduce cell damage caused by aging and environmental factors. (Imai & Guarente Nature Reviews Molecular Cell Biology 2014)3. Neurological healthNAD+ is associated with neuronal function and the repair of neurological damage. Preliminary studies suggest that NAD+ infusions may be beneficial in neurodegenerative diseases such as Parkinsons and Alzheimers. (Braidy et al. Frontiers in Aging Neuroscience 2019)4. Potential support in substance-use disordersSome clinical reports suggest that NAD+ infusions may help alleviate withdrawal symptoms and stabilise brain chemistry in people with alcohol or drug dependence. (Ross et al. Journal of Substance Use 2018)5. Anti-ageing effectsLower NAD+ levels are associated with signs of ageing and chronic diseases. Animal studies show that increasing NAD+ levels can promote longevity. (Yoshino et al. Cell Metabolism 2018)Risks and side effects of NAD+ infusions1. Insufficient long-term studiesAlthough NAD+ infusions have shown positive results in pilot studies comprehensive long-term studies on safety and efficacy in humans are currently lacking.2. Acute side effectsSome patients have reported symptoms such as nausea headaches hot flashes and dizziness during or after NAD+ infusions. These side effects appear to be dose-dependent. (Bogan & Brenner Annual Review of Nutrition 2008)3. Possible effects on metabolismAn increased NAD+ level could theoretically affect the balance of other metabolic pathways. This could be problematic especially for people with metabolic disorders such as diabetes or certain cancers.4. Cost and accessibilityNAD+ infusions are expensive and are not currently included in established clinical guidelines. They may therefore be considered experimental therapy.5. Infusion-related risksAs with any intravenous therapy there is a small risk of infections thrombosis or allergic reactions.ConclusionNAD+ infusions show promise for supporting cellular health particularly in age-related conditions and certain neurological and metabolic disorders. However their use remains experimental.Sources:[1] https://www.medrxiv.org/content/10.1101/2024.06.06.24308565v1.full[2] https://vitalivtherapy.com.au/studies-on-the-benefits-of-nad/[3] https://biorestorehealth.com/newtown-connecticut/what-is-nad-iv-therapy-process-benefits-and-risks/[4] https://aestha.co.uk/nad-iv-drip/[5] https://pmc.ncbi.nlm.nih.gov/articles/PMC9512238/[6] https://www.azivmedics.com/side-effects-of-nad-therapy[7] https://www.impnaples.com/post/the-science-behind-nad-iv-therapy-benefits-risks-and-effectivenessWhy are infusions so expensive?Members of our research group use this powder to prepare infusions for their personal use. For us this is acceptable because we are relying on our own judgement regarding purity and in particular the absence of microbial contamination. However if you professionally offer NAD infusions you have a special responsibility towards your patients/customers and therefore require a particularly high level of safety. This high level of safety is legally ensured by (elaborate) documentation requirements imposed on producers. These infusions are expensive not because the substance is purer or more effective but because extensive documentation requirements —under which every batch must be fully traceable from NAD productionto the final product—are intended to assure a high level of purity.TRANSLATE with x EnglishArabicHebrewPolishBulgarianHindiPortugueseCatalanHmong DawRomanianChinese SimplifiedHungarianRussianChinese TraditionalIndonesianSlovakCzechItalianSlovenianDanishJapaneseSpanishDutchKlingonSwedishEnglishKoreanThaiEstonianLatvianTurkishFinnishLithuanianUkrainianFrenchMalayUrduGermanMalteseVietnameseGreekNorwegianWelshHaitian CreolePersian TRANSLATE with COPY THE URL BELOW Back EMBED THE SNIPPET BELOW IN YOUR SITE Enable collaborative features and customize widget: Bing Webmaster PortalBack","mg","500","","","0.55","" 10010400457037,51310106345805,"125 mg NAD (β-nicotinamide adenine dinucleotide oxidized form; CAS 53-84-9) – 1 vial of lyophilisate for reconstitution to 10 ml – Returns excluded – Pharmacy product","AFEGA Research Group","Burg-Apotheke","AFEGA® und UTHEVER® > Alle Produkte > ampullen > billiger > BLOG / Forschung > Energie & Stoffwechsel > Gedächtnis Fokus & "Senioren-Gehirn" > NAD (Lyophilisate) > NAD+ > Regeneration & Zellschutz > Vorsorge","BA-NAD-125","637962701272","https://www.afega.shop/cdn/shop/files/afega-nad-lyophilisat-125mg-ampulle.webp?v=1775317494&width=1000","https://www.afega.shop/en/products/2-ml-losung-in-einem-5-ml-bernsteinflaschchen-mit-200-mg-nad-%CE%B2-nicotinamidadenindinukleotid-oxidierte-form-cas-53-84-9-ruckgabe-ausgeschlossen-kopie?variant=51310106345805&utm_source=web&utm_medium=cpc&utm_campaign=billiger","in stock",147.06,4,0,15,"Vermutlicher Liefertermin: Mitte Dezember","0.05 kg","125 mg NAD (β-Nicotinamidadenindinukleotid oxidierte Form; CAS 53-84-9) - 1 Inj. Fl. Trs.( Lyophilisat) in 10 ml - Ampulle - Rückgabe ausgeschlossen! Bei Außentemperaturen von mehr als 18 Grad wird Gekühlter Versand empfohlen! (Link anklicken und zur Bestellung hinzufügen!) -","125 mg NAD (β-Nicotinamide adenine dinucleotide oxidized form CAS 53-84-9) - No returns!We strongly recommend our blog post on NAD infusions.The vial is prepared by an authorised pharmacy only after an order is placed; the standard delivery time is therefore two to three weeks. We therefore recommend ordering this product separately as all items in an order are shipped together including for environmental reasons.1 vial of Ampuwa lyophilisate for reconstitution to 10 ml. Before use it must be reconstituted (i.e. dissolved) with a solvent (e.g. sterile water).Minimum shelf life: When stored correctly at 2–8°C and protected from light all infusion products we distribute remain stable for at least six months from the date of sale without loss of quality .For outside temperatures above 18 °C refrigerated shipping is recommended. Click the link to add it to your order.Restrictions for customers in Germany:In Germany this product may legally be supplied only to research institutions pharmacies laboratories clinics physicians non-medical practitionersand other professionals. Participants in the NAD+ study planned by the AFEGA Research Groupare exempt from this restriction. If you are willing to participate in this study—participation consists only of completing an anonymous online questionnaire—we can supply this product to you.*** Delivery to addresses outside the EU ***If the delivery address is outside the EU you bear the risk of any import problems in your country. Therefore do not order without ensuring that you are allowed to import these infusions! For deliveries outside the EU we ship exclusively by express because refrigeration is required. Please select the appropriate shipping option at checkout!Please note: These infusion products are excluded from the right of return because of their special delivery requirements.Advantages of lyophilized (freeze-dried) NAD+ powder compared to other formsStability and shelf lifeLyophilised NAD+ powder is particularly stable and has a longshelf life because of the freeze-drying process. The removal of water protects the sensitive molecule from degradation by hydrolysis or microbial contamination which is a common problem in liquid solutions. This allows NAD+ powder to be stored for longer periods without significant loss of NAD+.Purity and dosing accuracyThis lyophilised NAD+ is offered in pharmaceutical -grade or laboratory-grade quality. The powder can be dosed precisely and used flexibly for various applications (e.g. infusions injections cell culture). Compared to tablets or capsules which often contain fillers and excipients the powder offers a higher concentration of active ingredient and fewer impurities.Flexibility in use The powder can be reconstituted as needed for example with sterile saline for infusions or other suitable solvents for research purposes. This allows the concentration and method of administration to be adjusted individually which is not possible with premixed solutions or solid dosage forms.Transport and storageLyophilized powder is lighter and more space-saving to transport than liquid preparations. It does not require a continuous cold chain as long as it is stored dry and protected from light simplifying logistics and saving costs.Lower risk of chemical degradationIn the dry state NAD+ is significantly less susceptible to oxidation and other chemical degradation processes than in solution ensuring quality until use.Sources:[1] https://ch.iherb.com/blog/nad-nmn-aging-benefits/1640[2] https://www.zentrum-der-gesundheit.de/ernaehrung/nahrungsergaenzung/weitere-nahrungsergaenzungsmittel/nad[3] https://www.orthoknowledge.eu/artikel/nad-und-alterung[4] https://www.krebsinformationsdienst.de/fachkreise/nachrichten/detail/nahrungsergaenzungsmittel-nadh-gegen-krebs[5] https://www.gesundheits-lexikon.com/Anti-Aging-Medizin/Schluesselgene-und-Signalwege-in-der-Anti-Aging-Forschung/NAD-und-sein-Einfluss-auf-das-Altern[6] https://www.klartext-nahrungsergaenzung.de/faq/projekt-klartext-nem/nad-und-nmn-in-nahrungsergaenzungsmitteln-38606[7] https://www.ganzimmun.de/fileadmin/user_upload/NAD_LIN0062_001.pdf******NAD+ (nicotinamide adenine dinucleotide) is an essential coenzyme found in every cell of the body and plays a central role in energy metabolism and cellular repair mechanisms. NAD+ levels in the body decrease with age which is associated with a variety of age-related health problems. NAD+ infusions where NAD+ is administered directly into the bloodstream have gained popularity in recent years. The following outlines the current state of scientific research on the benefits and risks of this therapy.Potential benefits of NAD+ infusions1. Support for cellular metabolism and energy productionNAD+ plays a central role in energy metabolism particularly in mitochondrial function ; mitochondriaare the cells’ “powerhouses”. Studies show that increasing NAD+ levels can improve mitochondrial function and promote cell health. (Verdin et al. Cell Metabolism 2015)2. DNA repair and cellular stress responseNAD+ activates sirtuins and PARPs (poly-ADP-ribose polymerases) enzymes involved in DNA repair and the regulation of cellular stress. Higher NAD+ levels can therefore help reduce cell damage caused by aging and environmental factors. (Imai & Guarente Nature Reviews Molecular Cell Biology 2014)3. Neurological healthNAD+ is associated with neuronal function and the repair of neurological damage. Preliminary studies suggest that NAD+ infusions may be beneficial in neurodegenerative diseases such as Parkinsons and Alzheimers. (Braidy et al. Frontiers in Aging Neuroscience 2019)4. Potential support in substance-use disordersSome clinical reports suggest that NAD+ infusions may help alleviate withdrawal symptoms and stabilise brain chemistry in people with alcohol or drug dependence. (Ross et al. Journal of Substance Use 2018)5. Anti-aging effectsLower NAD+ levels are associated with aging and chronic diseases. Animal studies show that increasing NAD+ levels can promote longevity. (Yoshino et al. Cell Metabolism 2018)Risks and side effects of NAD+ infusions1. Insufficient long-term studiesAlthough NAD+ infusions have shown positive results in pilot studies comprehensive long-term studies on safety and efficacy in humans are currently lacking.2. Acute side effectsSome patients have reported symptoms such as nausea headaches hot flashes and dizziness during or after NAD+ infusions. These side effects appear to be dose-dependent. (Bogan & Brenner Annual Review of Nutrition 2008)3. Possible effects on metabolismAn increased NAD+ level could theoretically affect the balance of other metabolic pathways. This could be problematic especially for people with metabolic disorders such as diabetes or certain cancers.4. Cost and accessibilityNAD+ infusions are expensive and are not currently included in established clinical guidelines. They may therefore be considered experimental therapy.5. Infusion-related risksAs with any intravenous therapy there is a small risk of infections thrombosis or allergic reactions.ConclusionNAD+ infusions show promise for supporting cellular health particularly in age-related conditions and certain neurological and metabolic disorders. However their use remains experimental.Sources:[1] https://www.medrxiv.org/content/10.1101/2024.06.06.24308565v1.full[2] https://vitalivtherapy.com.au/studies-on-the-benefits-of-nad/[3] https://biorestorehealth.com/newtown-connecticut/what-is-nad-iv-therapy-process-benefits-and-risks/[4] https://aestha.co.uk/nad-iv-drip/[5] https://pmc.ncbi.nlm.nih.gov/articles/PMC9512238/[6] https://www.azivmedics.com/side-effects-of-nad-therapy[7] https://www.impnaples.com/post/the-science-behind-nad-iv-therapy-benefits-risks-and-effectivenessWhy are infusions so expensive?Members of our research group use this powder to make infusions for their personal use. For us this is acceptable because we are relying on our own judgement regarding purity and in particular the absence of microbial contamination. However if you professionally offer NAD infusions you have a special responsibility towards your patients/customers and therefore need a particularly high level of safety. Legally required extensive documentation by manufacturers—in this case a specially authorised pharmacy—is intended to provide this high level of assurance. These infusions are expensive not because the substance is purer or more effective but because extensive documentation requirements —under which every batch must be fully traceable from NAD productionto the final product—are intended to assure a high level of purity. TRANSLATE with x EnglishArabicHebrewPolishBulgarianHindiPortugueseCatalanHmong DawRomanianChinese SimplifiedHungarianRussianChinese TraditionalIndonesianSlovakCzechItalianSlovenianDanishJapaneseSpanishDutchKlingonSwedishEnglishKoreanThaiEstonianLatvianTurkishFinnishLithuanianUkrainianFrenchMalayUrduGermanMalteseVietnameseGreekNorwegianWelshHaitian CreolePersian TRANSLATE with COPY THE URL BELOW Back EMBED THE SNIPPET BELOW IN YOUR SITE Enable collaborative features and customize widget: Bing Webmaster PortalBack","mg","125","","","1.18","" 10084980162893,51667523502413,"10 × 500 mg NAD (β-nicotinamide adenine dinucleotide oxidized form; CAS 53-84-9) – 10 vials of lyophilisate for reconstitution to 10 ml each – Returns excluded – EU product (EU-compliant manufacturing)","AFEGA Research Group","NAD+ Shop","AFEGA® und UTHEVER® > Alle Produkte > ampullen > BLOG / Forschung > Energie & Stoffwechsel > Gedächtnis Fokus & "Senioren-Gehirn" > NAD (Lyophilisate) > NAD+ > Regeneration & Zellschutz > Vorsorge","AFEGA-NAD-500-10","637962701715","https://www.afega.shop/cdn/shop/files/ampullen-weisse-box.webp?v=1775315496&width=1000","https://www.afega.shop/en/products/500-mg-nad-%CE%B2-nicotinamidadenindinukleotid-oxidierte-form-cas-53-84-9-1-inj-fl-trs-in-10-ml-ampulle-ruckgabe-ausgeschlossen-kopie?variant=51667523502413&utm_source=web&utm_medium=cpc&utm_campaign=billiger","in stock",2436.97,0,0,0,"Ein bis 2 Wochen (für CH 3-4 Wochen)","0.5 kg","10 Inj. Fl. Trs. in 10 ml-Ampullen (Trs. = Trockensubstanz/Lyophilisat): Es handelt sich um Fläschchen die ein gefriergetrocknetes Pulver (Lyophilisat) enthalten. Bei Außentemperaturen von mehr als 18 Grad wird Gekühlter Versand empfohlen! (Link anklicken und zur Bestellung hinzufügen!)","10 × 500 mg NAD (β-nicotinamide adenine dinucleotide oxidised form; CAS 53-84-9) – Returns excludedWe strongly recommend our blog post on NAD infusions.GUARANTEE: Manufactured in Europe in compliance with all relevant pharmaceutical and regulatory requirements.Minimum shelf life: When stored correctly at 2–8°C and protected from light all infusion products we distribute remain stable for at least one year from the date of sale without loss of quality.10 vials each containing lyophilisate for reconstitution to 10 ml : These vials contain freeze-dried powder (lyophilisate). Before use it must be reconstituted (i.e. dissolved) with a solvent (e.g. sterile water). For outside temperatures above 18 °C refrigerated shipping is recommended. Click the link to add it to your order.*** Delivery to addresses outside the EU ***If the delivery address is outside the EU you bear the risk of any import problems in your country. Therefore do not order without ensuring that you are allowed to import these infusions! For deliveries outside the EU we ship exclusively by express because refrigeration is required. Please select the appropriate shipping option at checkout!Please note: These infusion products are excluded from the right of return because of their special delivery requirements.Advantages of lyophilized (freeze-dried) NAD+ powder compared to other formsStability and shelf lifeLyophilised NAD+ powder is particularly stable and has a longshelf life because of the freeze-drying process. Removing water protects the sensitive molecule from degradation through hydrolysis or microbial contamination both of which are common problems with liquid solutions. This allows NAD+ powder to be stored for longer periods without significant loss of NAD+.Purity and dosing accuracy This lyophilised NAD+ is offered in pharmaceutical -grade or laboratory-grade quality. The powder can be dosed precisely and used flexibly for various applications (e.g. infusions injections cell culture). Compared to tablets or capsules which often contain fillers and excipients the powder offers a higher concentration of active ingredient and fewer impurities.Flexibility in use The powder can be reconstituted as needed for example with sterile saline for infusions or other suitable solvents for research purposes. This allows the concentration and method of administration to be adjusted individually which is not possible with premixed solutions or solid dosage forms.Transport and storage Lyophilized powder is lighter and more space-saving to transport than liquid preparations. It does not require a continuous cold chain as long as it is stored dry and protected from light which simplifies logistics and saves costs.Lower risk of chemical degradation In its dry state NAD+ is significantly less susceptible to oxidation and other degradation processes than it is in solution helping to preserve quality until use.Sources:[1] https://ch.iherb.com/blog/nad-nmn-aging-benefits/1640[2] https://www.zentrum-der-gesundheit.de/ernaehrung/nahrungsergaenzung/weitere-nahrungsergaenzungsmittel/nad[3] https://www.orthoknowledge.eu/artikel/nad-und-alterung[4] https://www.krebsinformationsdienst.de/fachkreise/nachrichten/detail/nahrungsergaenzungsmittel-nadh-gegen-krebs[5] https://www.gesundheits-lexikon.com/Anti-Aging-Medizin/Schluesselgene-und-Signalwege-in-der-Anti-Aging-Forschung/NAD-und-sein-Einfluss-auf-das-Altern[6] https://www.klartext-nahrungsergaenzung.de/faq/projekt-klartext-nem/nad-und-nmn-in-nahrungsergaenzungsmitteln-38606[7] https://www.ganzimmun.de/fileadmin/user_upload/NAD_LIN0062_001.pdf******NAD+ (nicotinamide adenine dinucleotide) is an essential coenzyme found in every cell of the body and plays a central role in energy metabolism and cellular repair mechanisms. NAD+ levels in the body decline with age which is associated with a range of age-related health problems. NAD+ infusions in which NAD+ is administered directly into the bloodstream have gained popularity in recent years. The following outlines the current state of scientific research on the benefits and risks of this therapy.Potential benefits of NAD+ infusions1. Support for cellular metabolism and energy productionNAD+ plays a central role in energy metabolism particularly in mitochondrial function ; mitochondriaare the cells’ “powerhouses”. Studies show that increasing NAD+ levels can improve mitochondrial function and promote cell health. (Verdin et al. Cell Metabolism 2015)2. Improvement of DNA repair and cellular stress responseNAD+ activates sirtuins and PARPs (poly-ADP-ribose polymerases) enzymes involved in DNA repair and regulation of cell stress. Higher NAD+ levels can therefore help reduce cell damage caused by aging and environmental factors. (Imai & Guarente Nature Reviews Molecular Cell Biology 2014)3. Neurological healthNAD+ is associated with neuronal function and the repair of neurological damage. Preliminary studies suggest that NAD+ infusions may be beneficial in neurodegenerative diseases such as Parkinsons and Alzheimers. (Braidy et al. Frontiers in Aging Neuroscience 2019)4. Potential support in substance-use disordersSome clinical reports suggest that NAD+ infusions may help alleviate withdrawal symptoms and stabilise brain chemistry in people with alcohol or drug dependence. (Ross et al. Journal of Substance Use 2018)5. Anti-ageing effectsLower NAD+ levels are associated with signs of ageing and chronic diseases. Animal studies show that increasing NAD+ levels can promote longevity. (Yoshino et al. Cell Metabolism 2018)Risks and side effects of NAD+ infusions1. Insufficient long-term studiesAlthough NAD+ infusions have shown positive results in pilot studies comprehensive long-term studies on safety and efficacy in humans are currently lacking.2. Acute side effectsSome patients have reported symptoms such as nausea headaches hot flashes and dizziness during or after NAD+ infusions. These side effects appear to be dose-dependent. (Bogan & Brenner Annual Review of Nutrition 2008)3. Possible effects on metabolismAn increased NAD+ level could theoretically affect the balance of other metabolic pathways. This could be particularly problematic for people with metabolic disorders such as diabetes or certain cancers.4. Cost and accessibilityNAD+ infusions are expensive and are not currently included in established clinical guidelines. They may therefore be considered experimental therapy.5. Infusion-related risksAs with any intravenous therapy there is a small risk of infections thrombosis or allergic reactions.ConclusionNAD+ infusions show promise for supporting cellular health particularly in age-related conditions and certain neurological and metabolic disorders. However their use remains experimental.Sources:[1] https://www.medrxiv.org/content/10.1101/2024.06.06.24308565v1.full[2] https://vitalivtherapy.com.au/studies-on-the-benefits-of-nad/[3] https://biorestorehealth.com/newtown-connecticut/what-is-nad-iv-therapy-process-benefits-and-risks/[4] https://aestha.co.uk/nad-iv-drip/[5] https://pmc.ncbi.nlm.nih.gov/articles/PMC9512238/[6] https://www.azivmedics.com/side-effects-of-nad-therapy[7] https://www.impnaples.com/post/the-science-behind-nad-iv-therapy-benefits-risks-and-effectivenessWhy are infusions so expensive?Members of our research group use this powder to prepare infusions for their personal use. For us this is acceptable because we are relying on our own judgement regarding purity and in particular the absence of microbial contamination. However if you professionally offer NAD infusions you have a special responsibility towards your patients/customers and therefore require a particularly high level of safety. Legally required extensive documentation by manufacturers is intended to provide this high level of assurance. These infusions are expensive not because the substance is purer or more effective but because extensive documentation requirements—under which every batch must be fully traceable from NAD productionto the final product—are intended to assure a high level of purity.","mg","5000","","","0.49",""